公开(公告)号：US10227343B2

公开(公告)日：2019-03-12

申请号：US15547775

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Corey R. Hopkins ,  Joanne Bronson ,  Yong-Jin Wu ,  Kyle Emmitte ,  Joe Panarese ,  Darren W. Engers ,  Julie Engers

IPC: C07D471/04 ,  A61K31/496 ,  A61K31/437 ,  A61K31/554 ,  A61K31/553 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/541 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/502 ,  C07D401/12 ,  A61K31/4375 ,  C07D519/00 ,  A61K31/519 ,  A61K45/06

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US09980945B2

公开(公告)日：2018-05-29

申请号：US15540972

申请日：2016-01-13

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Sean Bollinger ,  Julie Engers

IPC: C07D401/14 ,  A61K31/437 ,  A61K31/423 ,  A61K31/4985 ,  C07D471/04 ,  C07D413/12 ,  A61K45/06

CPC classification number: A61K31/423 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K2300/00 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US20180022745A1

公开(公告)日：2018-01-25

申请号：US15547775

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Corey R. Hopkins ,  Joanne Bronson ,  Yong-Jin Wu ,  Kyle Emmitte ,  Joe Panarese ,  Darren W. Engers ,  Julie Engers

IPC: C07D471/04 ,  A61K31/496 ,  A61K31/437 ,  A61K31/554 ,  A61K31/553 ,  C07D487/04 ,  A61K31/4985 ,  A61K31/4725 ,  A61K31/541 ,  A61K31/4745 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/502 ,  C07D401/12 ,  A61K31/4375 ,  C07D519/00 ,  A61K31/519 ,  A61K45/06

CPC classification number: C07D471/04 ,  A61K31/437 ,  A61K31/4375 ,  A61K31/4725 ,  A61K31/4745 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/502 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/553 ,  A61K31/554 ,  A61K45/06 ,  C07D401/12 ,  C07D487/04 ,  C07D519/00 ,  A61K2300/00

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US20180021312A1

公开(公告)日：2018-01-25

申请号：US15540972

申请日：2016-01-13

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Sean Bollinger ,  Julie Engers

IPC: A61K31/423 ,  C07D413/12 ,  A61K45/06 ,  C07D471/04 ,  A61K31/437 ,  A61K31/4985

CPC classification number: A61K31/423 ,  A61K31/437 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/541 ,  A61K45/06 ,  A61K2300/00 ,  C07D413/12 ,  C07D471/04 ,  C07D487/04

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US10526323B2

公开(公告)日：2020-01-07

申请号：US15547781

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Joanne Bronson ,  Yong-Jin Wu ,  Jason Guernon

IPC: C07D403/12 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4162 ,  A61K45/06 ,  A61K31/416 ,  A61K31/437 ,  A61K31/4985 ,  A61K31/5377 ,  C07D231/56 ,  C07D519/00 ,  C07D413/14

Abstract: Compounds, including those of the following formula: wherein the variables are defined herein, which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.

公开(公告)号：US20180022746A1

公开(公告)日：2018-01-25

申请号：US15547781

申请日：2016-02-01

Applicant: Vanderbilt University

Inventor： P. Jeffrey Conn ,  Corey R. Hopkins ,  Craig W. Lindsley ,  Colleen M. Niswender ,  Darren W. Engers ,  Joe Panarese ,  Joanne Bronson ,  Yong-Jin Wu ,  Jason Guernon

IPC: C07D471/04 ,  C07D519/00 ,  C07D413/14 ,  C07D487/04 ,  C07D403/12

Abstract: Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.