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公开(公告)号：US20180022745A1
公开(公告)日：2018-01-25
申请号：US15547775
申请日：2016-02-01
发明人： P. Jeffrey Conn , Craig W. Lindsley , Colleen M. Niswender , Corey R. Hopkins , Joanne Bronson , Yong-Jin Wu , Kyle Emmitte , Joe Panarese , Darren W. Engers , Julie Engers
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437 , A61K31/554 , A61K31/553 , C07D487/04 , A61K31/4985 , A61K31/4725 , A61K31/541 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/502 , C07D401/12 , A61K31/4375 , C07D519/00 , A61K31/519 , A61K45/06
CPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4725 , A61K31/4745 , A61K31/496 , A61K31/4985 , A61K31/502 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K31/554 , A61K45/06 , C07D401/12 , C07D487/04 , C07D519/00 , A61K2300/00
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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公开(公告)号：US10227343B2
公开(公告)日：2019-03-12
申请号：US15547775
申请日：2016-02-01
发明人： P. Jeffrey Conn , Craig W. Lindsley , Colleen M. Niswender , Corey R. Hopkins , Joanne Bronson , Yong-Jin Wu , Kyle Emmitte , Joe Panarese , Darren W. Engers , Julie Engers
IPC分类号： C07D471/04 , A61K31/496 , A61K31/437 , A61K31/554 , A61K31/553 , C07D487/04 , A61K31/4985 , A61K31/4725 , A61K31/541 , A61K31/4745 , A61K31/506 , A61K31/5377 , A61K31/502 , C07D401/12 , A61K31/4375 , C07D519/00 , A61K31/519 , A61K45/06
摘要： Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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