Biopsy imaging devices with an imaging stage configured to rotate and tilt a biological sample, as well as a method for using it, are described. The stage can use rotating bearings or extendible, telescoping arms. The device has a white light for taking normal pictures and a near-infrared laser light for causing a fluorescence-biomolecule probed sample to fluoresce for fluorescence images in a light-tight housing. A set of both types of pictures are taken from angles around, above, and below the biopsy sample with one or more cameras to generate a 3-D model in a computer of the biopsy with fluorescence markings. The 3-D model can then be rendered and viewed on a display by a surgeon to determine if sufficient margins were removed from the patient.