Systems and methods are provided for mitigating motion sickness. When motion sickness is predicted, the motion sickness mitigation system alters vehicle performance, cabin conditions, and/or alerts the occupant to upcoming vehicle actions, to avoid or alleviate motion sickness. A controller includes a processor that receives an occupant profile and traffic information for an upcoming trip of the vehicle on a route. Using the occupant profile and the traffic information, the processor calculates whether the occupant will experience motion sickness when the vehicle travels on the route. A vehicle performance signal correlated to the calculation, is delivered by the processor to initiate motion sickness mitigation. The vehicle performance signal varies operation of a steering actuator, an acceleration actuator, and/or a brake actuator to implement the motion sickness mitigation.