Aspects disclosed in the detailed description include scheduled universal serial bus (USB) low-power operations. In this regard, in one aspect, a USB host controller determines a low-power operation schedule for a USB client device. The low-power operation schedule comprises one or more scheduled low-power operation periods, each corresponding to a respective entry time and a respective exit time. The USB host controller communicates the low-power operation schedule to the USB client device using one or more USB standard packets. By scheduling the one or more scheduled low-power operation periods with respective entry and exit times, the USB host controller or the USB client controller is able to start and end the one or more scheduled low-power operation periods without incurring additional signaling, thus improving efficiency of the USB low-power operation. Further, by communicating the low-power operation schedule using USB standard packets, it is possible to preserve compatibility with USB standards.