Invention Grant
- Patent Title: Tricyclic sulfones as RORγ modulators
-
Application No.: US15701818Application Date: 2017-09-12
-
Publication No.: US10273259B2Publication Date: 2019-04-30
- Inventor: Jingwu Duan , T. G. Murali Dhar , David Marcoux , Robert J. Cherney
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Elliott Korsen
- Main IPC: C07F9/6574
- IPC: C07F9/6574 ; C07D215/36 ; C07D409/04 ; C07D417/04 ; C07D209/30 ; C07D209/60 ; C07D209/70 ; C07D221/10 ; C07D401/06 ; C07D401/12 ; C07D403/06 ; C07D403/12 ; C07D405/06 ; C07D409/06 ; C07D413/06 ; C07D413/10 ; C07D413/12 ; C07D417/06 ; C07D417/12 ; C07D417/14 ; C07D471/04 ; C07D491/052 ; C07D491/107 ; C07D493/08 ; C07D495/04 ; C07D495/08

Abstract:
There are described RORγ modulators of the formula (I), and formula (II) or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein all substituents are defined herein. Also provided are pharmaceutical compositions comprising the same. Such compounds and compositions are useful in methods for modulating RORγ activity in a cell and methods for treating a subject suffering from a disease or disorder in which the subject would therapeutically benefit from modulation of RORγ activity, for example, autoimmune and/or inflammatory disorders.
Public/Granted literature
- US20180002358A1 TRICYCLIC SULFONES AS ROR GAMMA MODULATORS Public/Granted day:2018-01-04
Information query