Invention Grant
- Patent Title: Bacillus host
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Application No.: US15116933Application Date: 2015-02-06
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Publication No.: US10287592B2Publication Date: 2019-05-14
- Inventor: Evert Tjeerd Van Rij , Martine Spaans , Hendrikus Bernardus Carolus Hillebrand
- Applicant: DSM IP Assets B.V.
- Applicant Address: NL Heerlen
- Assignee: DSM IP Assets B.V.
- Current Assignee: DSM IP Assets B.V.
- Current Assignee Address: NL Heerlen
- Agency: McBee Moore Woodward & Vanik IP, LLC
- Agent Susan McBee; Chester Moore
- Priority: EP14154317 20140207
- International Application: PCT/EP2015/052552 WO 20150206
- International Announcement: WO2015/118126 WO 20150813
- Main IPC: C12N15/63
- IPC: C12N15/63 ; C12N15/75 ; C12N9/54 ; C12P21/02 ; C12N9/26 ; C12N9/24 ; C12P21/00

Abstract:
The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid construct, wherein the nucleic acid construct comprises a polynucleotide encoding a compound of interest or encoding a compound involved in the synthesis of a compound of interest operably linked to a promoter sequence allowing for expression of the polynucleotide in the host cell, wherein the promoter comprises a bacteriophage promoter sequence, more preferably a bacteriophage SPO1 promoter sequence. Said host cell can advantageously be used in a method of production of a compound of interest.
Public/Granted literature
- US20170175130A1 IMPROVED BACILLUS HOST Public/Granted day:2017-06-22
Information query
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