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    Mutant lipase and use thereof
    1.
    发明授权
    Mutant lipase and use thereof 有权

    公开(公告)号：US10829748B2

    公开(公告)日：2020-11-10

    申请号：US16305348

    申请日：2017-06-08

    Applicant: DSM IP Assets B.V.

    Inventor： Rene Marcel De Jong ,  Willem Bijleveld ,  Evert Tjeerd Van Rij

    IPC: C12N9/20 ,  C12N1/20 ,  C12N1/14 ,  C12N15/52 ,  C12N15/63 ,  A23C13/16 ,  A23C15/12 ,  A23C19/06 ,  A23C19/082

    Abstract: The present invention relates to a polypeptide having lipase activity wherein the polypeptide, which, when aligned with a polypeptide according to SEQ ID NO: 1, comprises at least one amino acid substitution resulting in Ser (S), Ala (A) or Leu (L) at position 246, Trp (W) at position 307, Leu (L) at position 345, Ile (I) at position 365, and/or Phe (F) at position 534, wherein the position is defined with reference to SEQ ID NO: 1, wherein Ala(A) at position 1 in SEQ ID NO: 1 is counted as number 1 and a method for preparing the polypeptide.The present invention further relates to a process for preparing a food product wherein a polypeptide according to the present invention is used.

    Phospholipase C
    3.
    发明授权
    Phospholipase C 有权

    公开(公告)号：US10457890B2

    公开(公告)日：2019-10-29

    申请号：US15564275

    申请日：2016-04-08

    Applicant: DSM IP ASSETS B.V.

    Inventor： Arjen Sein ,  Rene Marcel De Jong ,  Evert Tjeerd Van Rij ,  Willem Bijleveld ,  Maarten Hotse Wilbrink

    IPC: C11B3/00 ,  C12N9/16 ,  C12P7/64 ,  C12P7/20

    Abstract: The present invention relates to a polypeptide having phospholipase C activity, selected from the group consisting of i. a polypeptide comprising a mature polypeptide sequence of SEQ ID NO: 2; ii. a polypeptide that has least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98% or 99% identity to the mature polypeptide sequence of SEQ ID NO: 2; iii. a polypeptide encoded by a nucleic acid that hybridizes under medium stringency, preferably under high stringency conditions to the complementary strand of the mature polypeptide coding sequence of SEQ ID NO:1; iv. a polypeptide encoded by a nucleic acid that has at least 85%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% or 100% identity to the mature polypeptide coding sequence of SEQ ID NO: 1. A process for degumming a vegetable oil comprising contacting a vegetable oil comprising phospholipids with a polypeptide having phospholipase C activity of the invention or a composition of the invention, wherein phospholipids are hydrolyzed into diacylglycerol and phosphate ester and/or phosphate, separating the phosphate ester and/or phosphate from the vegetable oil wherein a degummed vegetable oil is obtained.

    Bacillus host
    5.
    发明授权
    Bacillus host 有权

    公开(公告)号：US10287592B2

    公开(公告)日：2019-05-14

    申请号：US15116933

    申请日：2015-02-06

    Applicant: DSM IP Assets B.V.

    Inventor： Evert Tjeerd Van Rij ,  Martine Spaans ,  Hendrikus Bernardus Carolus Hillebrand

    IPC: C12N15/63 ,  C12N15/75 ,  C12N9/54 ,  C12P21/02 ,  C12N9/26 ,  C12N9/24 ,  C12P21/00

    Abstract: The invention provides Bacillus host cell deficient in the production of a neutral protease and of a alkaline protease which host cell comprises a nucleic acid construct, wherein the nucleic acid construct comprises a polynucleotide encoding a compound of interest or encoding a compound involved in the synthesis of a compound of interest operably linked to a promoter sequence allowing for expression of the polynucleotide in the host cell, wherein the promoter comprises a bacteriophage promoter sequence, more preferably a bacteriophage SPO1 promoter sequence. Said host cell can advantageously be used in a method of production of a compound of interest.

    ORAL PREPARATION
    6.
    发明申请
    ORAL PREPARATION 审中-公开
    口腔准备

    公开(公告)号：US20150147365A1

    公开(公告)日：2015-05-28

    申请号：US14402143

    申请日：2013-05-13

    Applicant: DSM IP ASSETS B.V.

    Inventor： Luppo Edens ,  Evert Tjeerd Van Rij ,  Marco Jan Lambertus De Groot

    IPC: A61K8/66 ,  C12N9/02 ,  A61Q11/00 ,  A61K8/36 ,  A61K8/02

    CPC classification number: A61K8/66 ,  A23G1/423 ,  A23G3/366 ,  A23G4/123 ,  A61K8/0216 ,  A61K8/23 ,  A61K8/36 ,  A61K2800/92 ,  A61Q11/00 ,  C12N9/0051 ,  C12Y108/03004

    Abstract: The present invention relates to an oral composition comprising a volatile sulphur compound breath-odour controlling amount of methyl mercaptan oxidase. The oral composition may be used in a method for controlling breath-odour in a host, which method comprises applying the composition to the oral cavity of that host. The invention also provides a polypeptide having methyl mercaptan oxidase activity, wherein said polypeptide is: (a) a polypeptide comprising an amino acid sequence as set out in SEQ ID NO: 2; (b) a polypeptide comprising an amino acid sequence having at least 50% sequence identity with the amino acid sequence of SEQ ID NO: 2; (c) a polypeptide encoded by a polynucleotide comprising the polynucleotide sequence as set out in SEQ ID NO: 1 or SEQ ID NO: 3; or (d) a fragment of a polypeptide as defined in (a), (b) or (c).

    Abstract translation: 本发明涉及包含挥发性硫化合物呼吸气味控制量的甲硫醇氧化酶的口服组合物。 口服组合物可用于控制宿主呼吸气味的方法，该方法包括将该组合物施用于该宿主的口腔。 本发明还提供了具有甲硫醇氧化酶活性的多肽，其中所述多肽是：（a）包含SEQ ID NO：2所示氨基酸序列的多肽; （b）包含与SEQ ID NO：2的氨基酸序列具有至少50％序列同一性的氨基酸序列的多肽; （c）由包含SEQ ID NO：1或SEQ ID NO：3所示的多核苷酸序列的多核苷酸编码的多肽; 或（d）（a），（b）或（c）中定义的多肽的片段。

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