- 专利标题： Activation of bioluminescence by structural complementation
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申请号： US16023972申请日： 2018-06-29
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公开(公告)号： US10288605B2公开(公告)日： 2019-05-14
- 发明人: Andrew S. Dixon , Lance Encell , Mary Hall , Keith Wood , Monika Wood , Marie Schwinn , Brock F. Binkowski , Hicham Zegzouti , Nidhi Nath , Subhanjan Mondal , Said Goueli , Poncho Meisenheimer , Thomas Kirkland , James Unch , Dileep K. Pulukkunat , Matthew Robers , Melanie Dart , Thomas Machleidt
- 申请人： Promega Corporation
- 申请人地址： US WI Madison
- 专利权人： Promega Corporation
- 当前专利权人： Promega Corporation
- 当前专利权人地址： US WI Madison
- 代理机构： Casimir Jones SC
- 代理商 David W. Staple
- 主分类号： G01N31/00
- IPC分类号： G01N31/00 ; G01N33/53 ; G01N33/533 ; C07K14/435 ; C12Q1/66 ; C07K7/08 ; A61K51/08 ; C12N9/02 ; G01N33/542 ; G01N33/58
摘要：
Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
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