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公开(公告)号：US12065421B2
公开(公告)日：2024-08-20
申请号：US17841613
申请日：2022-06-15
申请人： PROMEGA CORPORATION
IPC分类号： C07D333/38 , C07C311/21 , C07C311/29 , C07C317/38 , C07D333/66 , C07D333/78 , G01N21/76 , G01N33/543 , G01N33/573
CPC分类号： C07D333/38 , C07C311/21 , C07C311/29 , C07C317/38 , C07D333/66 , C07D333/78 , G01N21/763 , G01N33/54306 , G01N33/573 , C07C2601/14 , C07C2602/10
摘要： Compounds that may selectively inhibit Oplophorus luciferase-derived bioluminescent complexes, e.g., NanoBiT® bioluminescent complex, are disclosed as well as compositions and kits comprising the compounds, and methods of using the compounds.
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公开(公告)号：US20240191211A1
公开(公告)日：2024-06-13
申请号：US18312487
申请日：2023-05-04
申请人： Promega Corporation
发明人： Rachel Friedman Ohana , Ce Shi , Robin Hurst , Mark A. Klein , Jian Cao , Thomas Kirkland , Connor Fitzgerald , Tetsuo Uyeda , Thomas Machleidt , Wenhui Zhou , Matthew A. Larsen , Hui Wang , Weiwei An , Karilyn Porter
CPC分类号： C12N9/0069 , B01J31/2295 , B01J35/39 , C12Y113/12013
摘要： Provided herein are systems, methods, and compositions for bioluminescence-triggered catalysis of bioorthogonal labeling chemistries in a proximity dependent manner. In particular, provided herein are bioluminescent proteins or complexes, luminophore substrates thereof, photocatalysts or photosensitizers, activatable labels, and systems thereof, and methods of catalytically activating the activatable labels via bioluminescence-triggered catalysis.
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公开(公告)号：US20240060059A1
公开(公告)日：2024-02-22
申请号：US18311977
申请日：2023-05-04
申请人： Promega Corporation
CPC分类号： C12N9/14 , C12N15/63 , C12Y308/01005
摘要： Provided herein are circularly-permuted (cp) dehalogenase variants that are capable of covalently binding to a haloalkyl ligand. In particular cp dehalogenase variants and peptides and polypeptides comprising split versions thereof that structurally assemble to form an active dehalogenase complexes are provided.
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![Process for preparing substituted imidazo[1,2-α]pyrazines](/abs-image/US/2023/10/10/US11781168B2/abs.jpg.150x150.jpg)
公开(公告)号：US11781168B2
公开(公告)日：2023-10-10
申请号：US17240435
申请日：2021-04-26
申请人： PROMEGA CORPORATION
发明人： Anton Shakhmin , Thomas Kirkland , Joel Walker , Thomas Machleidt , Mary Hall , Keith V. Wood
IPC分类号： C07D487/04 , C12Q1/66 , C07D519/00 , A61K49/00 , G01N33/58 , H04N1/60
CPC分类号： C12Q1/66 , A61K49/0013 , C07D487/04 , C07D519/00 , G01N33/581 , H04N1/6041 , G01N2333/90241
摘要： Described are processes for preparing substituted imidazo[1,2-a]pyrazine compounds of formula (I):
by reacting a compound of formula (xi):
with carbonyldiimidazole to form the compound of formula (I).-
公开(公告)号：US11692983B2
公开(公告)日：2023-07-04
申请号：US17159923
申请日：2021-01-27
申请人： Promega Corporation
CPC分类号： G01N30/8665 , G01N2030/027 , G01N2030/047 , G01N2030/8831 , H01J49/0009
摘要： The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities.
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公开(公告)号：US20230194515A1
公开(公告)日：2023-06-22
申请号：US17819784
申请日：2022-08-15
申请人： Promega Corporation
IPC分类号： G01N33/543 , C07D239/48 , G01N1/34 , G01N33/573
CPC分类号： G01N33/54353 , C07D239/48 , G01N1/34 , G01N33/573 , G01N21/6428
摘要： Provided herein are compounds that are broad-spectrum protein kinase binding agents, detectable tracers comprising such compounds, and method of use thereof for the detection of protein kinases.
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公开(公告)号：US11661623B2
公开(公告)日：2023-05-30
申请号：US17011597
申请日：2020-09-03
申请人： Promega Corporation
发明人： Brock Binkowski , Lance P. Encell , Mary Hall , Matthew B. Robers , Michael R. Slater , Keith V. Wood , Monika G. Wood , Dieter Klaubert , Poncho Meisenheimer , James Unch , Michael P. Valley
IPC分类号： C07D487/04 , C12N9/02 , C12Q1/66 , C12N15/52
CPC分类号： C12Q1/66 , C07D487/04 , C12N9/0004 , C12N9/0069 , C12N15/52 , C12Y113/12005 , C12Y113/12007 , A01K2217/072
摘要： An isolated polynucleotide encoding a modified luciferase polypeptide and substrates. The OgLuc variant polypeptide has at least 60% amino acid sequence identity to SEQ ID NO: 1 and at least one amino acid substitution at a position corresponding to an amino acid in SEQ ID NO: 1. The OgLuc variant polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the corresponding polypeptide of the wild-type Oplophorus luciferase.
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公开(公告)号：US20230097403A1
公开(公告)日：2023-03-30
申请号：US18049517
申请日：2022-10-25
申请人： Promega Corporation
IPC分类号： C07D307/42 , C07C317/28 , C07D307/80 , C07D311/58 , C12N9/12 , C12P19/34
摘要： The present disclosure includes compositions and methods for improved DNA amplification reactions. In particular, the present disclosure provides compositions and methods for hot-start PCR applications using DNA polymerase inhibitors that minimize non-specific DNA amplification by inactivating DNA polymerase at lower temperatures.
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9.发明申请公开(公告)号：US20230092932A1
公开(公告)日：2023-03-23
申请号：US18057578
申请日：2022-11-21
申请人： Promega Corporation
发明人： Melanie Dart , Thomas Smith , Thomas Kirkland , Thomas Machleidt , Keith Wood
IPC分类号： A61K49/00 , C07D487/04 , G01N33/58
摘要： Provided herein are compositions and methods for stabilizing coelenterazine and analogs or derivatives thereof, and for improving the solubility and reconstitution efficiency of coelenterazine and analogs and derivatives thereof.
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公开(公告)号：US20220252585A1
公开(公告)日：2022-08-11
申请号：US17729829
申请日：2022-04-26
申请人： Promega Corporation
发明人： Nidhi Nath , Rod Flemming , Marjeta Urh
IPC分类号： G01N33/543 , G01N33/58 , C07K16/28 , G01N33/94
摘要： Provided herein are compositions, kits, and methods for performing analyte detection immunoassays.
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