- Patent Title: Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists
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Application No.: US15387542Application Date: 2016-12-21
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Publication No.: US10294303B2Publication Date: 2019-05-21
- Inventor: Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, Jr. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
- Applicant: AMGEN INC.
- Applicant Address: US CA Thousand Oaks
- Assignee: AMGEN INC.
- Current Assignee: AMGEN INC.
- Current Assignee Address: US CA Thousand Oaks
- Agent Jonathan M. Dermott
- Main IPC: A61K39/39
- IPC: A61K39/39 ; C07K16/28 ; A61K38/26 ; A61K39/395 ; A61K9/00 ; A61K38/17 ; A61K39/00
Abstract:
Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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