公开(公告)号：US12060430B2

公开(公告)日：2024-08-13

申请号：US17332578

申请日：2021-05-27

申请人： AMGEN INC.

发明人： Junming Yie ,  Donghui Shi ,  David J. Lloyd ,  Jinghong Wang ,  Glenn N. Sivits, Jr. ,  Murielle M. Veniant-Ellison ,  Renee Komorowski ,  Neeraj Agrawal ,  Darren L. Bates ,  Brandon C. P. Clavette ,  Ian N. Foltz ,  Shu-yin Ho ,  Christopher Murawsky ,  Xiaoshan Min ,  Zhulun Wang

IPC分类号： A61K39/395 ,  A61K9/00 ,  A61K38/17 ,  A61K38/26 ,  C07K16/28 ,  A61K39/00

CPC分类号： C07K16/2869 ,  A61K9/0019 ,  A61K38/1703 ,  A61K38/26 ,  A61K39/3955 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2299/00 ,  C07K2317/21 ,  C07K2317/32 ,  C07K2317/33 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  A61K39/3955 ,  A61K2300/00

摘要： Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

公开(公告)号：US11248052B2

公开(公告)日：2022-02-15

申请号：US16282834

申请日：2019-02-22

申请人： Amgen, Inc.

发明人： Yang Li ,  Jennitte LeAnn Stevens ,  Chadwick Terence King ,  Ian Nevin Foltz ,  Gunasekaran Kannan ,  Junming Yie ,  Shaw-Fen Sylvia Hu

IPC分类号： C07K16/28 ,  C07K14/71 ,  C07K16/40 ,  A61K39/00

摘要： The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing β-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c.

公开(公告)号：US10905772B2

公开(公告)日：2021-02-02

申请号：US15872841

申请日：2018-01-16

申请人： AMGEN INC.

发明人： Yuan Cheng ,  Chawita Netirojjanakul ,  Jerry Ryan Holder ,  Bin Wu ,  James R. Falsey ,  Bradley J. Herberich ,  Kelvin Sham ,  Leslie P. Miranda ,  Shu-Chen Lu ,  Murielle M. Veniant-Ellison ,  Shanaka Stanislaus ,  Junming Yie ,  Jing Xu

IPC分类号： A61K47/68 ,  A61K38/26 ,  A61P3/10 ,  C07K16/28 ,  A61K39/395

摘要： Methods of treating metabolic diseases and disorders using a composition comprising an antigen binding protein specific for the GIPR polypeptide conjugated to a GLP-1 receptor agonist are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the composition comprises an antibody or functional fragment thereof comprising a cysteine at one or more conjugation site(s) wherein the GLP-1 receptor agonist is conjugated to the antibody or functional fragment thereof through the side-chain of the cysteine residue.

公开(公告)号：US11046774B2

公开(公告)日：2021-06-29

申请号：US16285118

申请日：2019-02-25

申请人： AMGEN INC.

发明人： Junming Yie ,  Donghui Shi ,  David J. Lloyd ,  Jinghong Wang ,  Glenn N. Sivits, Jr. ,  Murielle M. Veniant-Ellison ,  Renee Komorowski ,  Neeraj Agrawal ,  Darren L. Bates ,  Brandon C. P. Clavette ,  Ian N. Foltz ,  Shu-yin Ho ,  Christopher Murawsky ,  Xiaoshan Min ,  Zhulun Wang

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61K38/17 ,  A61K38/26 ,  A61K9/00 ,  A61K39/00

摘要： Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

公开(公告)号：US20190276546A1

公开(公告)日：2019-09-12

申请号：US16285118

申请日：2019-02-25

申请人： AMGEN INC.

发明人： Junming Yie ,  Donghui Shi ,  David J. Lloyd ,  Jinghong Wang ,  Glenn N. Sivits, JR. ,  Murielle M. Veniant-Ellison ,  Renee Komorowski ,  Neeraj Agrawal ,  Darren L. Bates ,  Brandon C. P. Clavette ,  Ian N. Foltz ,  Shu-yin Ho ,  Christopher Murawsky ,  Xiaoshan Min ,  Zhulun Wang

IPC分类号： C07K16/28 ,  A61K9/00 ,  A61K38/26 ,  A61K39/395 ,  A61K38/17

摘要： Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.

公开(公告)号：US10294303B2

公开(公告)日：2019-05-21

申请号：US15387542

申请日：2016-12-21

申请人： AMGEN INC.

发明人： Junming Yie ,  Donghui Shi ,  David J. Lloyd ,  Jinghong Wang ,  Glenn N. Sivits, Jr. ,  Murielle M. Veniant-Ellison ,  Renee Komorowski ,  Neeraj Agrawal ,  Darren L. Bates ,  Brandon C. P. Clavette ,  Ian N. Foltz ,  Shu-yin Ho ,  Christopher Murawsky ,  Xiaoshan Min ,  Zhulun Wang

IPC分类号： A61K39/39 ,  C07K16/28 ,  A61K38/26 ,  A61K39/395 ,  A61K9/00 ,  A61K38/17 ,  A61K39/00

摘要： Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.