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1.发明授权公开(公告)号：US12060430B2
公开(公告)日：2024-08-13
申请号：US17332578
申请日：2021-05-27
Applicant: AMGEN INC.
Inventor： Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, Jr. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
CPC classification number: C07K16/2869 , A61K9/0019 , A61K38/1703 , A61K38/26 , A61K39/3955 , A61K2039/505 , A61K2039/54 , C07K2299/00 , C07K2317/21 , C07K2317/32 , C07K2317/33 , C07K2317/41 , C07K2317/52 , C07K2317/71 , C07K2317/76 , C07K2317/92 , A61K39/3955 , A61K2300/00
Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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公开(公告)号：US12258411B2
公开(公告)日：2025-03-25
申请号：US17831398
申请日：2022-06-02
Applicant: AMGEN INC. , AMGEN RESEARCH (MUNICH) GmbH
Inventor： Nathan William Pierce , Agnieszka Kielczewska , Wentao Chen , Olivier Nolan-Stevaux , Darren L. Bates , Lisa Winkel , Christoph Dahlhoff , Tobias Raum , Claudia Bluemel , Jonas Karl-Josef Honer
Abstract: The present invention provides anti-CCR8 antibodies and antigen-binding fragments thereof, and methods of making and using said anti-CCR8 antibodies and antigen-binding fragments thereof.
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Patent Agency Ranking
公开(公告)号：US20240002545A1
公开(公告)日：2024-01-04
申请号：US18252442
申请日：2021-11-09
Applicant: AMGEN INC.
Inventor： Timothy RILEY , Fernando GARCES , Zhulun WANG , Bram Estes , Darren L. Bates
IPC: C07K16/46
CPC classification number: C07K16/468 , C07K2317/55 , C07K2317/64 , C07K2317/31
Abstract: The ability to generate a single antibody-based construct that can recognize multiple targets simultaneously, is paramount to advance many therapeutics candidates to clinic. Often, this implies extensive protein design with vary degrees of success. In the case of multispecific antibodies, the driving of the HC/LC pairing in the Fab region represents one of the most difficult challenges yet in the field of multispecific engineering. Described here is the discovery of a new single chain Fab module that utilizes a novel linker between VL-CL and VH-CH1 domains which will further enable the production of multispecifics.
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公开(公告)号：US11046774B2
公开(公告)日：2021-06-29
申请号：US16285118
申请日：2019-02-25
Applicant: AMGEN INC.
Inventor： Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, Jr. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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公开(公告)号：US20190276546A1
公开(公告)日：2019-09-12
申请号：US16285118
申请日：2019-02-25
Applicant: AMGEN INC.
Inventor： Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, JR. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
IPC: C07K16/28 , A61K9/00 , A61K38/26 , A61K39/395 , A61K38/17
Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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公开(公告)号：US10294303B2
公开(公告)日：2019-05-21
申请号：US15387542
申请日：2016-12-21
Applicant: AMGEN INC.
Inventor： Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, Jr. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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7.发明授权公开(公告)号：US12252540B2
公开(公告)日：2025-03-18
申请号：US17332578
申请日：2021-05-27
Applicant: AMGEN INC.
Inventor： Junming Yie , Donghui Shi , David J. Lloyd , Jinghong Wang , Glenn N. Sivits, Jr. , Murielle M. Veniant-Ellison , Renee Komorowski , Neeraj Agrawal , Darren L. Bates , Brandon C. P. Clavette , Ian N. Foltz , Shu-yin Ho , Christopher Murawsky , Xiaoshan Min , Zhulun Wang
Abstract: Methods of treating metabolic diseases and disorders using an antigen binding protein specific for the GIPR polypeptide are provided. In various embodiments the metabolic disease or disorder is type 2 diabetes, obesity, dyslipidemia, elevated glucose levels, elevated insulin levels and diabetic nephropathy. In certain embodiments the antigen binding protein is administered in combination with a GLP-1 receptor agonist.
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