Technologies for secure enumeration of USB devices include a computing device having a USB controller and a trusted execution environment (TEE). The TEE may be a secure enclave protected secure enclave support of the processor. In response to a USB device connecting to the USB controller, the TEE sends a secure command to the USB controller to protect a device descriptor for the USB device. The secure command may be sent over a secure channel to a static USB device. A driver sends a get device descriptor request to the USB device, and the USB device responds with the device descriptor. The USB controller redirects the device descriptor to a secure memory buffer, which may be located in a trusted I/O processor reserved memory region. The TEE retrieves and validates the device descriptor. If validated, the TEE may enable the USB device for use. Other embodiments are described and claimed.