- 专利标题: Heteroaromatic derivatives and their use as pharmaceuticals
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申请号: US15121103申请日: 2015-02-24
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公开(公告)号: US10301305B2公开(公告)日: 2019-05-28
- 发明人: Dmytro Atamanyuk , Francis Chevreuil , Fabien Faivre , Nicolas Lecointe , Benoît Ledoussal , Chrystelle Oliveira , Christophe Simon , Vincent Gerusz
- 申请人: MUTABILIS
- 申请人地址: FR Paris
- 专利权人: MUTABILIS
- 当前专利权人: MUTABILIS
- 当前专利权人地址: FR Paris
- 代理机构: Duane Morris LLP
- 优先权: EP14305285 20140227
- 国际申请: PCT/EP2015/053857 WO 20150224
- 国际公布: WO2015/128333 WO 20150903
- 主分类号: C07D471/04
- IPC分类号: C07D471/04 ; A61K31/437 ; A61K31/4545 ; C07D519/00 ; C07D403/14 ; A61K31/4184 ; C07D401/14 ; A61K31/454 ; C07D487/04 ; C07D403/04 ; A61K31/4439 ; C07D235/08 ; A61K31/496 ; C07D401/04 ; C07D405/14 ; C07D417/04 ; A61K31/428 ; A61K31/4709 ; C07D491/052 ; A61K31/436 ; A61K31/498 ; C07D413/04 ; A61K31/538 ; C07D498/06 ; A61K31/5383 ; A61K31/4725 ; A61K31/423 ; A61K31/4375 ; A61K31/4355 ; C07D491/048 ; A61K31/506 ; A61K45/06 ; C07D235/04 ; C07D405/04 ; C07D491/04
摘要:
The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C—R1 and Y is N or C—R2, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; R1 is Hydrogen or a substituent as defined in the application; R2 is Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.
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