公开(公告)号：US10301305B2

公开(公告)日：2019-05-28

申请号：US15121103

申请日：2015-02-24

申请人： MUTABILIS

发明人： Dmytro Atamanyuk ,  Francis Chevreuil ,  Fabien Faivre ,  Nicolas Lecointe ,  Benoît Ledoussal ,  Chrystelle Oliveira ,  Christophe Simon ,  Vincent Gerusz

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/4545 ,  C07D519/00 ,  C07D403/14 ,  A61K31/4184 ,  C07D401/14 ,  A61K31/454 ,  C07D487/04 ,  C07D403/04 ,  A61K31/4439 ,  C07D235/08 ,  A61K31/496 ,  C07D401/04 ,  C07D405/14 ,  C07D417/04 ,  A61K31/428 ,  A61K31/4709 ,  C07D491/052 ,  A61K31/436 ,  A61K31/498 ,  C07D413/04 ,  A61K31/538 ,  C07D498/06 ,  A61K31/5383 ,  A61K31/4725 ,  A61K31/423 ,  A61K31/4375 ,  A61K31/4355 ,  C07D491/048 ,  A61K31/506 ,  A61K45/06 ,  C07D235/04 ,  C07D405/04 ,  C07D491/04

摘要： The invention relates to the compounds (I) and their acids and bases salts: wherein: Formula (I) the dotted line indicates a double bond; X is N or C—R1 and Y is N or C—R2, X and Y not being simultaneously N; A is selected from the group consisting of phenyl, naphthyl and (5-11) membered monocyclic or bicyclic unsaturated cycle or heterocycle possibly substituted as defined in the application, and A can also comprise either a further (4-7) membered heterocycle, said heterocycle being a monocycle, fused, saturated or unsaturated, the polycyclic system then comprising up to 14 members and up to 5 heteroatoms selected from N, O and S; B is selected from the group of substituents as defined in the application, or B is a 4 or (6-10) membered mono or bicyclic saturated or unsaturated heterocycle containing 1-3 heteroatoms selected from N, O and S, linked by a carbon atom, and possibly substituted as defined in the application; R1 is Hydrogen or a substituent as defined in the application; R2 is Hydrogen or Halogen; their preparation, their use in the antibacterial prevention and therapy, alone or in association with antibacterials, antivirulence agents or drugs reinforcing the host innate immunity, and pharmaceutical compositions and associations containing them.

公开(公告)号：US10183943B2

公开(公告)日：2019-01-22

申请号：US15571964

申请日：2016-05-06

申请人： MUTABILIS

发明人： Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Nicolas Lecointe ,  Benoît Ledoussal ,  Frédéric Le Strat ,  Sébastien Richard ,  Christophe Simon ,  Sophie Vomscheid ,  Julie Brias ,  Sophie Briet ,  Fabien Faivre ,  Géraldine Le Fralliec ,  Chrystelle Oliveira

IPC分类号： C07D471/08 ,  A61P31/04 ,  A61K31/439 ,  A61K31/444 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/546 ,  C07D519/00

摘要： The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as β-lactamase inhibitors and/or as antibacterial agents.

公开(公告)号：US10570131B2

公开(公告)日：2020-02-25

申请号：US15563483

申请日：2016-03-30

申请人： MUTABILIS

发明人： Julie Brias ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Fabien Faivre ,  Benoît Ledoussal ,  Frédéric Le Strat ,  Sébastien Richard ,  Christophe Simon ,  Sophie Vomscheid

IPC分类号： C07D471/08 ,  A61K31/439 ,  A61K31/546

摘要： The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as β-lactamase inhibitors and/or as antibacterial agents.

公开(公告)号：US20200017496A1

公开(公告)日：2020-01-16

申请号：US16483878

申请日：2018-02-06

申请人： MUTABILIS

发明人： Julien BARBION ,  Audrey CARAVANO ,  Sophie CHASSET ,  Francis CHEVREUIL ,  Benoît LEDOUSSAL ,  Frédéric LE STRAT ,  François MOREAU ,  Marie-Hélène QUERNIN ,  Ludovic WAECKEL ,  Christophe SIMON ,  Chrystelle OLIVEIRA

IPC分类号： C07D471/08 ,  A61P31/04

摘要： The present invention relates to compound of formula (I) and their use for treating bacterial infections.

公开(公告)号：US20200017495A1

公开(公告)日：2020-01-16

申请号：US16483702

申请日：2018-02-06

申请人： MUTABILIS

发明人： Damien Bonnard ,  Julie Brias ,  Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Nicolas Lecointe ,  Benoît Ledoussal ,  Erwann Le Rouzic ,  Frédéric Le Strat ,  François Moreau ,  Marie-Hélène Quernin ,  Ludovic Waeckel

IPC分类号： C07D471/08 ,  A61K45/06 ,  A61K31/439 ,  A61P31/04

摘要： The present invention relates to compound of formula (I) and their use for treating bacterial infections.

公开(公告)号：US11530227B2

公开(公告)日：2022-12-20

申请号：US17263664

申请日：2019-07-30

申请人： MUTABILIS

发明人： Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Nicolas Lecointe ,  Frédéric Le Strat ,  Chrystelle Oliveira ,  Christophe Simon

IPC分类号： C07D495/18 ,  C07D471/18 ,  C07D471/22 ,  C07D495/22 ,  A61P31/04

摘要： The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

公开(公告)号：US20210277019A1

公开(公告)日：2021-09-09

申请号：US17263664

申请日：2019-07-30

申请人： MUTABILIS

发明人： Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Nicolas Lecointe ,  Frédéric Le Strat ,  Chrystelle Oliveira ,  Christophe Simon

IPC分类号： C07D495/18 ,  C07D471/18 ,  C07D471/22 ,  C07D495/22

摘要： The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

公开(公告)号：US20210275542A1

公开(公告)日：2021-09-09

申请号：US17263662

申请日：2019-07-29

申请人： MUTABILIS

发明人： Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Frédéric Le Strat ,  Christophe Simon ,  Julie Brias ,  Rémi Lebel

IPC分类号： A61K31/551 ,  A61P31/04 ,  C07D513/18 ,  C07D495/18 ,  A61K31/43 ,  A61K31/545 ,  A61K31/431 ,  A61K31/407 ,  A61K31/427 ,  A61K31/546

摘要： The present invention relates to compounds of formula (I) and their use for treating or preventing a bacterial infection or as an antibacterial agent and/or as a β-lactamase inhibitor.

公开(公告)号：US10072006B2

公开(公告)日：2018-09-11

申请号：US15563519

申请日：2016-03-30

申请人： MUTABILIS

发明人： Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Fabien Faivre ,  Nicolas Lecointe ,  Benoît Ledoussal ,  Frédéric Le Strat ,  Sébastien Richard ,  Christophe Simon ,  Sophie Vomscheid ,  Julie Brias ,  Julien Barbion

IPC分类号： C07D471/08 ,  A61K31/529 ,  A61K45/06 ,  A61K31/546

CPC分类号： C07D471/08 ,  A61K31/439 ,  A61K31/529 ,  A61K31/546 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention relates to heterocyclic compounds, their process of preparation, pharmaceutical compositions comprising these compounds and use thereof, optionally in combination with other antibacterial agents and/or beta-lactam compounds, for the prevention or treatment of bacterial infections. The present invention also relates to the use of these compounds as β-lactamase inhibitors and/or as antibacterial agents.

公开(公告)号：US10722520B2

公开(公告)日：2020-07-28

申请号：US16338355

申请日：2017-09-29

申请人： MUTABILIS

发明人： Julien Barbion ,  Audrey Caravano ,  Sophie Chasset ,  Francis Chevreuil ,  Fabien Faivre ,  Rémi Lebel ,  Nicolas Lecointe ,  Benoît Ledoussal ,  Frédéric Le-Strat ,  Christophe Simon ,  Chrystelle Oliveira ,  Géraldine Le Fralliec ,  Julie Brias ,  Laurence Farescour ,  Sophie Vomscheid ,  Sébastien Richard

IPC分类号： A61K31/551 ,  A61K31/546 ,  A61K31/439 ,  A61K45/06 ,  C07D471/08 ,  C07D403/04 ,  C07D403/14 ,  C07D413/14 ,  C07D417/14 ,  A61P31/04

摘要： A compound of formula (I) or a racemate, an enantiomer, a diastereoisomer, a geometric isomer or a pharmaceutically acceptable salt thereof, and its use as antibacterial agent.