A network interface card configuration method and a resource management center are provided. According to the method, after obtaining a network interface card allocation request of an operating system that runs in a first CPU core, a resource management center selects, from M physical network interface cards and based on a network parameter of a network service required by the operating system, a target physical network interface card that conforms to the network parameter. Further, the resource management center selects at least one target hardware queue from each target physical network interface card and sends a command message to a network interface card controller. After receiving queue information of the target hardware queue from the network interface card controller, the resource management center send an instruction message to a CPU controller on a CPU board to instruct the CPU controller to construct a virtual network interface card.