- Patent Title: Method for screening agents promoting skin barrier function and method for evaluating skin barrier function taking epidermal serine racemase and/or D-serine level as indicator
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Application No.: US15123274Application Date: 2015-03-05
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Publication No.: US10337064B2Publication Date: 2019-07-02
- Inventor: Yosuke Tojo , Masato Iino , Chieko Mizumoto , Yuzo Yoshida , Yuko Matsuura , Hisashi Mori
- Applicant: Shiseido Company, Ltd
- Applicant Address: JP Tokyo
- Assignee: SHISEIDO COMPANY, LTD.
- Current Assignee: SHISEIDO COMPANY, LTD.
- Current Assignee Address: JP Tokyo
- Agency: Foley & Lardner LLP
- Priority: JP2014-043073 20140305; WOPCT/JP2014/055680 20140305
- International Application: PCT/JP2015/056570 WO 20150305
- International Announcement: WO2015/133591 WO 20150911
- Main IPC: A61K8/64
- IPC: A61K8/64 ; C12N9/90 ; C12Q1/6876 ; G01N33/50 ; A61K38/01 ; A61K36/9068 ; A61K36/28 ; G01N33/68 ; C12Q1/6883 ; A61K36/899 ; A61K8/97 ; A61Q19/00
Abstract:
The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.
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