公开(公告)号：US10907208B2

公开(公告)日：2021-02-02

申请号：US16412993

申请日：2019-05-15

申请人： Shiseido Company, Ltd

发明人： Yosuke Tojo ,  Masato Iino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Yuko Matsuura ,  Hisashi Mori

IPC分类号： C12N9/90 ,  C12Q1/6876 ,  G01N33/50 ,  A61K38/01 ,  A61K36/9068 ,  A61K36/28 ,  G01N33/68 ,  C12Q1/6883 ,  A61K36/899 ,  A61K8/9789 ,  A61K8/9794 ,  A61K8/64 ,  A61Q19/00

摘要： The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.

公开(公告)号：US10337064B2

公开(公告)日：2019-07-02

申请号：US15123274

申请日：2015-03-05

申请人： Shiseido Company, Ltd

发明人： Yosuke Tojo ,  Masato Iino ,  Chieko Mizumoto ,  Yuzo Yoshida ,  Yuko Matsuura ,  Hisashi Mori

IPC分类号： A61K8/64 ,  C12N9/90 ,  C12Q1/6876 ,  G01N33/50 ,  A61K38/01 ,  A61K36/9068 ,  A61K36/28 ,  G01N33/68 ,  C12Q1/6883 ,  A61K36/899 ,  A61K8/97 ,  A61Q19/00

摘要： The purpose of the present invention is to develop a method for screening drugs having the effect of increasing skin barrier function in in vitro studies and to evaluate barrier function in the skin. Candidate drugs can be screened by using the activity and/or expression level of serine racemase as an indicator.