发明授权
- 专利标题： Inhibition of formation of amyloid β-protein fibrils using cactus mucilage extracts
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申请号： US15706086申请日： 2017-09-15
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公开(公告)号： US10391135B2公开(公告)日： 2019-08-27
- 发明人: Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
- 申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
- 申请人地址： US FL Tampa
- 专利权人： University of South Florida
- 当前专利权人： University of South Florida
- 当前专利权人地址： US FL Tampa
- 代理机构： Smith & Hopen, P.A.
- 代理商 Michele L. Lawson
- 主分类号： A61K36/00
- IPC分类号： A61K36/00 ; A61K36/33 ; A61K9/00
摘要：
A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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