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公开(公告)号：US10946056B2
公开(公告)日：2021-03-16
申请号：US16502850
申请日：2019-07-03
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US20190328811A1
公开(公告)日：2019-10-31
申请号：US16502850
申请日：2019-07-03
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US10391135B2
公开(公告)日：2019-08-27
申请号：US15706086
申请日：2017-09-15
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US20180078595A1
公开(公告)日：2018-03-22
申请号：US15706086
申请日：2017-09-15
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
CPC分类号： A61K36/33 , A61K9/0085 , A61K2236/15 , A61K2236/331 , A61K2236/53
摘要： Alzheimer' s disease (AD) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of Amyloid β-Protein (Aβ) into plaques. Cactus mucilage extracted from Opuntia ficus-indica was analyzed in disturbing the aggregation pathway of Amyloid β-Protein (Aβ) fibrils and α-synuclein. Mucilage is a pectin polysaccharide with a backbone of α-D-galacturonic acid and β-L-rhamnose and a branch of arabinose or xylose. Two different fractions of mucilage can be extracted: pectin gelling extract which forms gels in the presence of Ca2+ ions (GE) and non-gelling extract (NE). The effectiveness of mucilage in disturbing the formation of Aβ fibrils was evaluated. Aβ monomeric species have been incubated along with different concentration of the mucilage extract in vitro. The aggregation kinetics of the Aβ proteins were monitored by Fourier transform infrared (FTIR) spectroscopy. Transmission electron microscopy (TEM) was used to monitor the aggregation process and fibril morphology. Our results indicate that introducing mucilage induces changes in the secondary structures of the Aβ peptides and results in amyloid detribalized structures. Our experimental results support the effectiveness of cactus mucilage in interfering with protein accumulation pathway and targeting the Aβ plaques.
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