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公开(公告)号：US10946056B2
公开(公告)日：2021-03-16
申请号：US16502850
申请日：2019-07-03
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US20190328811A1
公开(公告)日：2019-10-31
申请号：US16502850
申请日：2019-07-03
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US10391135B2
公开(公告)日：2019-08-27
申请号：US15706086
申请日：2017-09-15
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
摘要： A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.
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公开(公告)号：US20180078595A1
公开(公告)日：2018-03-22
申请号：US15706086
申请日：2017-09-15
申请人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
发明人： Norma A. Alcantar , David Morgan , Zeinab Veisi , Leonid Breydo , Vladimir N. Uversky , Ryan G. Toomey , Tunan Peng , Eva Stephanie Lobbens
CPC分类号： A61K36/33 , A61K9/0085 , A61K2236/15 , A61K2236/331 , A61K2236/53
摘要： Alzheimer' s disease (AD) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of Amyloid β-Protein (Aβ) into plaques. Cactus mucilage extracted from Opuntia ficus-indica was analyzed in disturbing the aggregation pathway of Amyloid β-Protein (Aβ) fibrils and α-synuclein. Mucilage is a pectin polysaccharide with a backbone of α-D-galacturonic acid and β-L-rhamnose and a branch of arabinose or xylose. Two different fractions of mucilage can be extracted: pectin gelling extract which forms gels in the presence of Ca2+ ions (GE) and non-gelling extract (NE). The effectiveness of mucilage in disturbing the formation of Aβ fibrils was evaluated. Aβ monomeric species have been incubated along with different concentration of the mucilage extract in vitro. The aggregation kinetics of the Aβ proteins were monitored by Fourier transform infrared (FTIR) spectroscopy. Transmission electron microscopy (TEM) was used to monitor the aggregation process and fibril morphology. Our results indicate that introducing mucilage induces changes in the secondary structures of the Aβ peptides and results in amyloid detribalized structures. Our experimental results support the effectiveness of cactus mucilage in interfering with protein accumulation pathway and targeting the Aβ plaques.
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公开(公告)号：US08163418B1
公开(公告)日：2012-04-24
申请号：US12268772
申请日：2008-11-11
申请人： Andres M. Cardenas-Valencia , Norma A. Alcantar , Xiaoling Ding , Ryan G. Toomey , Lawrence C. Langebrake
发明人： Andres M. Cardenas-Valencia , Norma A. Alcantar , Xiaoling Ding , Ryan G. Toomey , Lawrence C. Langebrake
CPC分类号： H01M8/16 , H01M6/32 , Y02E60/527
摘要： A system and method for improving electrochemical power sources through the dispensing, encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
摘要翻译： 一种用于通过分配，封装和分散到电化学电池的电偶室中来改善电化学电源的系统和方法。 该方法的特征包括优化涉及所需能量产生反应的化学品的浓度水平。
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6.发明授权Enhanced targeted drug delivery system via chitosan hydrogel and chlorotoxin 有权通过壳聚糖水凝胶和氯毒素增强靶向药物递送系统公开(公告)号：US09522114B1
公开(公告)日：2016-12-20
申请号：US14671439
申请日：2015-03-27
CPC分类号： A61K47/24 , A61K9/0024 , A61K9/06 , A61K9/1272 , A61K9/1277 , A61K31/337 , A61K38/1767 , A61K47/36
摘要： Specific drug delivery to tumor cells without affecting normal cells is a major challenge in cancer treatment. The present invention incorporates embedding nonionic surfactant vesicles (niosomes) containing an anti-cancer therapeutic agent with chlorotoxin into a thermosensitive chitosan hydrogel network. Chitosan has mucoadhesive property which can be used in the targeting of the tumor cells with the mucin over expression. Chlorotoxin is a 36 amino acid peptide obtained from Leiurus quinquestriatus scorpion venom which binds preferentially to tumor cells of neuroectodermal origin but not to normal cells. The incorporation of chlorotoxin along with niosomes in the chitosan hydrogel is used as the second targeting strategy to further improve the specific delivery of drugs to tumor cells such as glioma.
摘要翻译： 不影响正常细胞的肿瘤细胞的特异性药物递送是癌症治疗中的主要挑战。 本发明将含有抗癌治疗剂的非离子型表面活性剂囊泡（niosomes）与氯毒素嵌入热敏壳聚糖水凝胶网络中。 壳聚糖具有粘膜粘附性，可用于靶向肿瘤细胞与粘蛋白过度表达。 蝎毒素是一种从Leiurus quinquestriatus蝎子毒液获得的36个氨基酸肽，其优先结合神经外胚层起源但不与正常细胞的肿瘤细胞结合。 将氯毒素与壳聚糖水凝胶中的niosomes结合用作第二靶向策略，以进一步改善药物对肿瘤细胞如胶质瘤的特异性递送。
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公开(公告)号：US08501338B1
公开(公告)日：2013-08-06
申请号：US13090801
申请日：2011-04-20
申请人： Andres M. Cardenas-Valencia , Norma A. Alcantar , Xiaoling Ding , Ryan G. Toomey , Lawrence C. Langebrake
发明人： Andres M. Cardenas-Valencia , Norma A. Alcantar , Xiaoling Ding , Ryan G. Toomey , Lawrence C. Langebrake
CPC分类号： H01M8/16 , Y02E60/527
摘要： A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
摘要翻译： 一种用于通过分配封装和分散到电化学电池的电室来改善电化学电源的系统和方法。 该方法的特征包括优化涉及所需能量产生反应的化学品的浓度水平。
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公开(公告)号：US07943259B1
公开(公告)日：2011-05-17
申请号：US11958841
申请日：2007-12-18
申请人： Andres M. Cardenas-Valencia , Norma Alcantar , Xiaoling Ding , Ryan G. Toomey , Larry Langebrake
发明人： Andres M. Cardenas-Valencia , Norma Alcantar , Xiaoling Ding , Ryan G. Toomey , Larry Langebrake
IPC分类号： H01M8/16
CPC分类号： H01M8/16 , Y02E60/527
摘要： A system and method for improving electrochemical power sources through the dispensing encapsulation and dispersion into galvanic chambers of an electrochemical cell. Features of the method include the optimization of the concentration levels of chemicals involved in desired energy producing reactions.
摘要翻译： 一种用于通过分配封装和分散到电化学电池的电室来改善电化学电源的系统和方法。 该方法的特征包括优化涉及所需能量产生反应的化学品的浓度水平。
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