公开(公告)号：US10946056B2

公开(公告)日：2021-03-16

申请号：US16502850

申请日：2019-07-03

申请人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

发明人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

IPC分类号： A61K36/00 ,  A61K36/33 ,  A61M5/142 ,  A61P25/28

摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.

公开(公告)号：US20190177571A1

公开(公告)日：2019-06-13

申请号：US16280207

申请日：2019-02-20

申请人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

发明人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

IPC分类号： C09D167/04 ,  C09D7/61 ,  C08G63/60 ,  C08G63/68 ,  A61K36/33

摘要： Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and stability under abrupt changes in temperature and environment. CLMs can be engineered at the nanoscale and readily impregnated with metals and metal oxides materials.

公开(公告)号：US10934453B2

公开(公告)日：2021-03-02

申请号：US16280207

申请日：2019-02-20

申请人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

发明人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

IPC分类号： C09D167/00 ,  C09D167/04 ,  A61K36/33 ,  C09D7/61 ,  C08G63/60 ,  C08G63/68 ,  C08K3/08 ,  C08K3/34 ,  C08K3/36

摘要： Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and stability under abrupt changes in temperature and environment. CLMs can be engineered at the nanoscale and readily impregnated with metals and metal oxides materials.

公开(公告)号：US20190328811A1

公开(公告)日：2019-10-31

申请号：US16502850

申请日：2019-07-03

申请人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

发明人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

IPC分类号： A61K36/33 ,  A61M5/142 ,  A61P25/28

摘要： A method of slowing progression of an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.

公开(公告)号：US20180037768A1

公开(公告)日：2018-02-08

申请号：US15783226

申请日：2017-10-13

申请人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

发明人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

IPC分类号： C09D167/04 ,  C08G63/68 ,  C09D7/12 ,  C08G63/60

CPC分类号： C09D167/04 ,  A61K36/33 ,  C08G63/60 ,  C08G63/681 ,  C08K3/08 ,  C08K3/34 ,  C08K3/36 ,  C08K2003/0831 ,  C08K2003/0856 ,  C09D7/61

摘要： Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and stability under abrupt changes in temperature and environment. CLMs can be engineered at the nanoscale and readily impregnated with metals and metal oxides materials.

公开(公告)号：US10391135B2

公开(公告)日：2019-08-27

申请号：US15706086

申请日：2017-09-15

申请人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

发明人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

IPC分类号： A61K36/00 ,  A61K36/33 ,  A61K9/00

摘要： A method of treating an amyloid disease by administration of cactus mucilage extract from Opuntia ficus-indicia is presented. Both gelling and non-gelling cactus mucilage extracts were found to induce changes in the secondary structures of the amyloid beta peptides thus interfering with formation of Aβ fibrils and aggregation of Aβ fibrils into plaques.

公开(公告)号：US10253208B2

公开(公告)日：2019-04-09

申请号：US15783226

申请日：2017-10-13

申请人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

发明人： Norma Arcelia Alcantar ,  Ryan Gates Toomey ,  Fei Guo ,  Zeinab Veisi ,  Tunan Peng

IPC分类号： C09D167/04 ,  A61K36/33 ,  C09D7/61 ,  C08G63/60 ,  C08G63/68 ,  C08K3/08 ,  C08K3/34 ,  C08K3/36

摘要： Cutin-based devices, coatings and methods of producing such devices and coatings are presented herein. Cutin-like materials (CLMs) are presented which mimic and adapt coatings found in nature for the next generation of functional coatings. Cutin has several advantages including excellent UV resistance, natural resistance to bacteria and viruses, noncorrosive, and stability under abrupt changes in temperature and environment. CLMs can be engineered at the nanoscale and readily impregnated with metals and metal oxides materials.

公开(公告)号：US20180078595A1

公开(公告)日：2018-03-22

申请号：US15706086

申请日：2017-09-15

申请人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

发明人： Norma A. Alcantar ,  David Morgan ,  Zeinab Veisi ,  Leonid Breydo ,  Vladimir N. Uversky ,  Ryan G. Toomey ,  Tunan Peng ,  Eva Stephanie Lobbens

IPC分类号： A61K36/33 ,  A61K9/00

CPC分类号： A61K36/33 ,  A61K9/0085 ,  A61K2236/15 ,  A61K2236/331 ,  A61K2236/53

摘要： Alzheimer' s disease (AD) is the common neurodegenerative disorder characterized by the formation of extraneuronal accumulation of amyloid fibrils and intracellular neurofibrillary tangles of Amyloid β-Protein (Aβ) into plaques. Cactus mucilage extracted from Opuntia ficus-indica was analyzed in disturbing the aggregation pathway of Amyloid β-Protein (Aβ) fibrils and α-synuclein. Mucilage is a pectin polysaccharide with a backbone of α-D-galacturonic acid and β-L-rhamnose and a branch of arabinose or xylose. Two different fractions of mucilage can be extracted: pectin gelling extract which forms gels in the presence of Ca2+ ions (GE) and non-gelling extract (NE). The effectiveness of mucilage in disturbing the formation of Aβ fibrils was evaluated. Aβ monomeric species have been incubated along with different concentration of the mucilage extract in vitro. The aggregation kinetics of the Aβ proteins were monitored by Fourier transform infrared (FTIR) spectroscopy. Transmission electron microscopy (TEM) was used to monitor the aggregation process and fibril morphology. Our results indicate that introducing mucilage induces changes in the secondary structures of the Aβ peptides and results in amyloid detribalized structures. Our experimental results support the effectiveness of cactus mucilage in interfering with protein accumulation pathway and targeting the Aβ plaques.