Systems and related methods for controlling an ear stimulation device with a personal computing device are described. Multiple factors, including a mood of the user, a user control input, and a secondary factor input are used in controlling the ear stimulation device. Secondary factors include, a variety of factors relating to or influencing the state of the user, including but not limited to, environmental conditions, sleep, diet, or various activities of the user. User inputs can be open-ended or selected from a menu, for example. In an aspect, a correlation module correlates mood of the user to other factors, and control of stimulation is based thereon. In various aspects, the system is also responsive to inputs from sensors or computing networks. In an aspect, the earpiece delivers an audio output such as music from an audio player.