Hybrid trigate and nanowire CMOS device architecture, and methods of fabricating hybrid trigate and nanowire CMOS device architecture, are described. For example, a semiconductor structure includes a semiconductor device of a first conductivity type having a plurality of vertically stacked nanowires disposed above a substrate. The semiconductor structure also includes a semiconductor device of a second conductivity type opposite the first conductivity type, the second semiconductor device having a semiconductor fin disposed above the substrate.