- 专利标题： Pharmaceutical composition for preventing or treating asthma comprising Pistacia weinmannifolia J. Poiss. ex Franch extract or fraction thereof
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申请号： US14902439申请日： 2014-07-01
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公开(公告)号： US10413579B2公开(公告)日： 2019-09-17
- 发明人: Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
- 申请人： Korea Research Institute of Bioscience and Biotechnology
- 申请人地址： KR Daejeon
- 专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人： Korea Research Institute of Bioscience and Biotechnology
- 当前专利权人地址： KR Daejeon
- 代理机构： Cesari & McKenna, LLP
- 优先权： KR10-2013-0076696 20130701
- 国际申请： PCT/KR2014/005844 WO 20140701
- 国际公布： WO2015/002430 WO 20150108
- 主分类号： A61K36/22
- IPC分类号： A61K36/22 ; A23L33/105
摘要：
The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.