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公开(公告)号：US10751378B2
公开(公告)日：2020-08-25
申请号：US15304316
申请日：2015-04-17
发明人： Sei Ryang Oh , Kyung Seop Ahn , Seung Hyung Kim , In Sik Shin , Hang Jin , Jung Hee Kim , Hyung Won Ryu , Wan Yi Li , Sang Woo Lee , Joong Ku Lee , Sang Ho Choi
IPC分类号： A61K36/22 , A23L33/105 , A61K9/00 , A61K31/12 , A61P11/00
摘要： The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-α, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.
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公开(公告)号：US20170173095A1
公开(公告)日：2017-06-22
申请号：US14902439
申请日：2014-07-01
发明人： Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
IPC分类号： A61K36/22 , A23L33/105
CPC分类号： A61K36/22 , A23L33/105 , A23V2002/00 , A61K2236/33
摘要： The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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公开(公告)号：US10413579B2
公开(公告)日：2019-09-17
申请号：US14902439
申请日：2014-07-01
发明人： Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
IPC分类号： A61K36/22 , A23L33/105
摘要： The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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公开(公告)号：US20210052536A1
公开(公告)日：2021-02-25
申请号：US17010806
申请日：2020-09-02
发明人： Sei-Ryang Oh , Ok-Kyoung Kwon , Chan Mi Chun , Su Ui Lee , Kyung Seop Ahn , In Sik Shin , Seung Hyung Kim , Hye Kyung Kim , JongKoo Kang , Yong-Hae Han , Tae-Suk Lee , Ki Young Sohn
IPC分类号： A61K31/231
摘要： The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
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公开(公告)号：US10172816B2
公开(公告)日：2019-01-08
申请号：US15384302
申请日：2016-12-19
发明人： Yongnam Lee , Ji-seok Yoo , Dae-hee Shin , Byung-hwan Ryoo , Kyung Seop Ahn , Sei Ryang Oh , Hyeong Kyu Lee , In Sik Shin , Doo Young Kim , Ok-Kyoung Kwon , Hyuk Hwan Song , Seung Hyung Kim , SuUi Lee
IPC分类号： A61K31/192 , A61K31/7048 , A61K36/80 , A61K31/194 , A23L33/105
摘要： A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
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公开(公告)号：US09655871B2
公开(公告)日：2017-05-23
申请号：US14780503
申请日：2014-04-09
发明人： Yongnam Lee , Ji-seok Yoo , Dae-hee Shin , Byung-hwan Ryoo , Kyung Seop Ahn , Sei Ryang Oh , Hyeong Kyu Lee , In Sik Shin , Doo Young Kim , Ok-Kyoung Kwon , Hyuk Hwan Song , Seung Hyung Kim , SuUi Lee
IPC分类号： A61K31/192 , A61K31/7048 , A61K36/80 , A61K31/194 , A23L33/105
CPC分类号： A61K31/192 , A23L33/105 , A61K31/194 , A61K31/7048 , A61K36/80 , A61K2236/00
摘要： A composition comprising a purified extract isolated from Pseudolysimachion rotundum var. subintegrum containing abundant amount of active ingredient or the compounds isolated therefrom as an active ingredient for treating a chronic obstructive pulmonary disease and the use thereof. Inventive purified extract and compounds showed potent anti-COPD activity without beta-2-receptor agonistic response through various in vivo tests as well as in vitro test. Therefore, it can be used as the therapeutics or functional health food for treating and preventing chronic obstructive pulmonary disease (COPD).
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