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公开(公告)号：US10413579B2
公开(公告)日：2019-09-17
申请号：US14902439
申请日：2014-07-01
发明人： Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
IPC分类号： A61K36/22 , A23L33/105
摘要： The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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2.发明申请INGENANE-TYPE DITERPENE COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING VIRAL INFECTIOUS DISEASES CONTAINING SAME 有权氨基酸类化合物和用于治疗或预防含有其的病毒性感染性疾病的药物组合物公开(公告)号：US20140371311A1
公开(公告)日：2014-12-18
申请号：US14352978
申请日：2012-09-28
发明人： Sei Ryang Oh , Jae Wha Kim , Hyeong Kyu Lee , Piseth Khiev , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Kyung Seop Ahn
摘要： The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
摘要翻译： 本发明涉及来源于大戟属的异丙烷型二萜化合物和用于治疗或预防病毒性传染病的药物组合物，用于预防或改善病毒性传染病的保健功能性食品，以及用于增强干扰素 - γ，其包含正壬烷型二萜化合物。 此外，本发明涉及一种预防或治疗病毒感染性疾病的方法，包括以具有病毒感染性疾病发生的受试者或其治疗有效剂量的风险给予该组合物。
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公开(公告)号：US10376553B2
公开(公告)日：2019-08-13
申请号：US15573207
申请日：2016-05-13
发明人： Sei-Ryang Oh , Kyung Seop Ahn , Su Ui Lee , Hyung Won Ryu , Doo-Young Kim , Hyeong Kyu Lee , Ok-Kyoung Kwon , Jung Hee Kim , Hyun-Jun Lee , In-Sik Shin
IPC分类号： A61K36/575 , A61P11/00 , A61K31/34 , A61K31/36 , A61P9/00 , A61P35/00 , A61K31/357 , A61K9/00 , A61K47/38
摘要： A pharmaceutical composition includes any of an extract of Magnoliae flos, a fraction or an active fraction obtained by fractionation thereof with an organic solvent, and a compound separated therefrom as an active ingredient. The extract of Magnoliae flos, the fraction or the active fraction obtained by fractionation thereof with an organic solvent, or the compound separated therefrom inhibits the expression of MUC5AC induced by TNF-α and the promoter activity in human lung cancer mucosal cells (H292), reduces the number of inflammatory cells in the bronchoalveolar lavage fluid of the chronic obstructive pulmonary disease mouse model, inhibits the production of reactive oxygen species, and reduces the cytokines; and therefore are effective in preventing or treating chronic obstructive pulmonary disease.
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公开(公告)号：US20170173095A1
公开(公告)日：2017-06-22
申请号：US14902439
申请日：2014-07-01
发明人： Kyung Seop Ahn , Sei Ryang Oh , Ok Kyoung Kwon , In Sik Shin , Hyung Won Ryu , Sang Woo Lee , Joong Ku Lee , Hyeong Kyu Lee , Sang Ho Choi , Doo Young Kim , Jung Hee Kim , Li Wan Yi , Jin Hang
IPC分类号： A61K36/22 , A23L33/105
CPC分类号： A61K36/22 , A23L33/105 , A23V2002/00 , A61K2236/33
摘要： The present invention relates to a composition for preventing or treating asthma comprising a Pistacia weinmannifolia J. Poiss. ex Franch extract or a fraction thereof. The Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention does not exhibit toxicity, inhibits the generation of NO, IL-4, IL-5, and IL-13 and the generation of reactive oxygen species in the bronchial tubes, and has significantly induced the alleviation of airway hyperresponsiveness, inhibition of the infiltration of inflammatory cells into the bronchial tubes, and reduction of inflammatory cells in bronchoalveolar lavage fluid in an ovalbumin-induced asthma mouse model. In addition, the Pistacia weinmannifolia J. Poiss. ex Franch extract or the fraction thereof according to the present invention effectively inhibits the secretion of immunoglobulins in serum, secretion of mucus in the bronchial tubes, and infiltration of inflammatory cells into lung tissue and thus can be usefully used as a safe preparation for preventing and treating asthma.
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公开(公告)号：US10751378B2
公开(公告)日：2020-08-25
申请号：US15304316
申请日：2015-04-17
发明人： Sei Ryang Oh , Kyung Seop Ahn , Seung Hyung Kim , In Sik Shin , Hang Jin , Jung Hee Kim , Hyung Won Ryu , Wan Yi Li , Sang Woo Lee , Joong Ku Lee , Sang Ho Choi
IPC分类号： A61K36/22 , A23L33/105 , A61K9/00 , A61K31/12 , A61P11/00
摘要： The present invention relates to a composition for suppressing chronic obstructive pulmonary disease (COPD) comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom and, more particularly, to a pharmaceutical composition for preventing or treating COPD comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom; a food composition for preventing or improving COPD, and the compound isolated therefrom. The composition comprising a Pistacia weinmannifolia extract, a fraction thereof, or a compound isolated therefrom, according to the present invention, is not toxic, suppresses the invasion of inflammatory cells into the bronchial tube of a COPD-induced animal model, and effectively suppresses the expression of CXCL-1, TNF-α, or MIP-2. In addition, due to the use of a safety-proven herbal drug as a raw material, the composition of the present invention can resolve various side-effects of existing therapeutic agents for COPD, chronic obstructive bronchitis, chronic bronchiolitis, emphysema, multiple sclerosis, and acute and chronic inflammation, and thus can be effectively used as a composition for preventing, treating and remedying COPD.
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6.发明授权公开(公告)号：US09820963B2
公开(公告)日：2017-11-21
申请号：US15022546
申请日：2013-11-08
发明人： Sei Ryang Oh , Yong Yeon Cho , Hyung Won Ryu , Cheol Jung Lee , Hye Suk Lee , Doo Young Kim , Jung Hee Kim , Kyung Seop Ahn , Mee Hyun Lee , Hyeong Kyu Lee
IPC分类号： A61K31/34 , A61K36/898 , A61K45/06 , A61K31/36 , A61K36/575 , A61K31/05
CPC分类号： A61K31/34 , A23V2002/00 , A61K31/05 , A61K31/36 , A61K36/575 , A61K36/898 , A61K45/06 , A61K2300/00 , A23V2200/308 , A23V2250/21 , A61K31/06
摘要： The present invention relates to a pharmaceutical composition for preventing, ameliorating, or treating cancer. More specifically, the present invention relates to a pharmaceutical composition for preventing or treating cancer including a lignan compound having a specific chemical structure (Chemical Formula 1); a health functional food composition for preventing or ameliorating cancer including the lignan compound; and a method for preventing, ameliorating, or treating cancer using the composition.Further, the present invention relates to a use of the lignan compound in the preparation of a pharmaceutical composition or a health functional food composition for preventing, ameliorating, or treating cancer.
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7.发明授权Ingenane-type diterpene compound, and pharmaceutical composition for treating or preventing viral infectious diseases containing same 有权异根型二萜化合物，以及用于治疗或预防含有其的病毒感染性疾病的药物组合物公开(公告)号：US09481630B2
公开(公告)日：2016-11-01
申请号：US14352978
申请日：2012-09-28
发明人： Sei Ryang Oh , Jae Wha Kim , Hyeong Kyu Lee , Piseth Khiev , Doo Young Kim , Jung Hee Kim , Jae Sung Song , Kyung Seop Ahn
摘要： The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.
摘要翻译： 本发明涉及来源于大戟属的异丙烷型二萜化合物和用于治疗或预防病毒性传染病的药物组合物，用于预防或改善病毒性传染病的保健功能性食品，以及用于增强干扰素 - γ，其包含正壬烷型二萜化合物。 此外，本发明涉及一种预防或治疗病毒感染性疾病的方法，包括以具有病毒感染性疾病发生的受试者或其治疗有效剂量的风险给予该组合物。
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公开(公告)号：US10053443B2
公开(公告)日：2018-08-21
申请号：US15449465
申请日：2017-03-03
申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY , DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人： Kyeong Lee , Sei-Ryang Oh , Kyung Seop Ahn , Ok-Kyoung Kwon , Doo-Young Kim , Hyung Won Ryu , Jung Hee Kim , Xuezhen Xu
IPC分类号： A61K31/343 , C07D307/86 , A23L33/10
CPC分类号： C07D307/86 , A23L33/10 , A23V2002/00 , A61K31/05 , A61K31/343 , C07D307/78 , C07D307/79 , C07D307/80 , C07D307/81
摘要： The present invention relates to a novel 2-phenylbenzofuran derivative or a pharmaceutically acceptable salt thereof, a production method for the same, and a pharmaceutical composition for preventing or treating an inflammatory disease comprising the same as an active ingredient, and the novel 2-phenylbenzofuran derivative or the pharmaceutically acceptable salt thereof according to the present invention is outstandingly effective in suppressing NO, IL-6, and TNF-alpha induced by macrophages, and therefore can advantageously be used in a pharmaceutical composition for preventing or treating an inflammatory disease.
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