利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

262 条记录 (耗时 0.035 秒)

    HORIZONTAL ELECTROPHORESIS APPARATUS
    1.
    发明申请
    HORIZONTAL ELECTROPHORESIS APPARATUS 有权

    公开(公告)号：US20220397550A1

    公开(公告)日：2022-12-15

    申请号：US17776158

    申请日：2020-10-22

    申请人： T-MAC CO., LTD. ,  Korea Research Institute of Bioscience and Biotechnology

    发明人： Sung Hyun Kang ,  Jong Taek Park ,  Dong Woo Lim ,  Woo Jong Ha ,  Heung Seon Shin

    IPC分类号： G01N27/447

    摘要： A horizontal electrophoresis apparatus according to the present invention comprises a first electrode and a second electrode arranged at respective sides of an electrophoretic gel and each in close contact with one side of the electrophoretic gel. By using the first electrode and the second electrode each in close contact with one side of the electrophoretic gel, the horizontal electrophoresis apparatus enables electric current to flow across the entire cross section of the electrophoretic gel, and thus can prevent an electric current difference from occurring between the upper and lower ends of the electrophoretic gel and solve the problem of a reduction in the resolution of protein bands.

    METHOD FOR PRODUCING CAR GENE-INTRODUCED NK CELLS AND USE THEREOF
    6.
    发明申请
    METHOD FOR PRODUCING CAR GENE-INTRODUCED NK CELLS AND USE THEREOF 有权

    公开(公告)号：US20220184128A1

    公开(公告)日：2022-06-16

    申请号：US17598916

    申请日：2020-03-27

    申请人： KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

    发明人： Yee Sook CHO ,  Han-Seop KIM ,  Jae Yun KIM ,  Binna SEOL

    IPC分类号： A61K35/17 ,  C12N5/0783 ,  C07K14/725 ,  C07K14/705 ,  C07K14/47 ,  C07K14/435 ,  A61P35/00

    摘要： The present invention relates to a method for producing induced natural killer (iNK) cells, into which a chimeric antigen receptor (CAR) gene encoding a CAR is introduced, iNK cells produced by the method, and a cell therapy composition and a pharmaceutical composition for preventing or treating cancer, comprising the iNK cells.
    The method according to the present invention has the effects of producing the iNK cells, into which a CAR gene is introduced, with high efficiency through direct reprogramming from isolated cells without limiting an initial cell, and directly producing the same without a differentiation process, thereby simplifying the production process and reducing costs and time. The method according to the present invention has the effect of producing excellent NK cells having enhanced safety by directly producing NK cells from human somatic cells that are easy to obtain, without passing through induced pluripotent stem cells produced through conventional reprogramming technology. In addition, the iNK cells, into which a CAR gene is introduced, produced by the method, have an excellent cancer cell killing ability, and thus can be effectively utilized as a cell therapy composition or a pharmaceutical composition for preventing or treating cancer.