A self-administered tamper-evident drug detection system. The system includes a biometric detection surface for each of a user's right and left hands, configured to identify the user and prevent tamper by continuously capturing biometric information from each of the user's right and left hands while the system is administering a drug detection test. The system further includes a collection device to administer the drug detection test by exposing a sample collection device to a user's mouth to collect a saliva sample.