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公开(公告)号：US10433787B2
公开(公告)日：2019-10-08
申请号：US15324387
申请日：2015-07-06
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Kiran S. Kanukurthy , Matthew D. Moore , Raj Rajagopal , Michael E. Hamerly
IPC: A61B5/00 , A61B5/1172 , A61B5/0205 , A61B10/00 , A61B5/145 , G01N33/94 , G06K9/00 , A61B5/024 , A61B5/053 , A61B5/1171
Abstract: A self-administered tamper-evident drug detection system. The system includes a biometric detection surface for each of a user's right and left hands, configured to identify the user and prevent tamper by continuously capturing biometric information from each of the user's right and left hands while the system is administering a drug detection test. The system further includes a collection device to administer the drug detection test by exposing a sample collection device to a user's mouth to collect a saliva sample.
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公开(公告)号：US20180051313A1
公开(公告)日：2018-02-22
申请号：US15556664
申请日：2016-03-15
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Raj Rajagopal , Manjiri T. Kshirsagar , Evan D. Brutinel , James E. Aysta
CPC classification number: C12Q1/24 , B01D46/00 , C12M1/12 , C12M1/26 , C12M1/34 , C12Q1/04 , G01N1/10 , G01N1/405 , G01N2001/4088
Abstract: Methods of detecting microorganisms in a fluid sample are provided. The method includes providing a nonwoven article, providing a fluid sample suspected of containing at least one microorganism strain or target cellular analyte, and contacting the fluid sample with the nonwoven article such that at least a portion of the at least one microorganism strain or target cellular analyte is bound to the nonwoven article. The nonwoven article includes a fibrous porous matrix and a concentration agent particles enmeshed in the fibrous porous matrix. The method further includes placing the microorganism strain- or target cellular analyte-bound nonwoven article in contact with at least one detection reagent and detecting the presence of the bound microorganism strain or bound target cellular analyte. Devices and kits containing the devices, for contacting a fluid sample with a nonwoven article, are also provided. The device includes a sample container, a filter holder, a nonwoven article, and an adaptor configured to interface the filter holder with a receptacle.
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公开(公告)号：US20160310940A1
公开(公告)日：2016-10-27
申请号：US15105448
申请日：2014-12-16
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Raj Rajagopal , Kurt J. Halverson , Shawn C. Dodds , Ramasubramani Kuduva Raman Thanumoorthy
CPC classification number: B01L3/5021 , B01L2300/0681 , B01L2300/0851 , B01L2300/0858 , B01L2300/123 , C12Q1/10
Abstract: Systems and methods for concentrating a sample and detecting an analyte of interest. The system can include a sample detection container that can include a microcavity. The microcavity can include a top opening, a base, and a longitudinal axis. The container can further include a wall that extends to the microcavity, wherein at least a portion of the wall located adjacent the top opening of the microcavity has a slope that is oriented at an effective angle α with respect to the longitudinal axis of the microcavity. The effective angle α can be greater than 45 degrees and less than 90 degrees, and at least the portion of the wall located adjacent the top opening of the microcavity that is oriented at the effective angle α can have a length of at least 5 times a transverse dimension of the microcavity.
Abstract translation: 用于浓缩样品和检测感兴趣的分析物的系统和方法。 该系统可以包括可以包括微腔的样本检测容器。 微腔可以包括顶部开口，底部和纵向轴线。 容器还可以包括延伸到微腔的壁，其中位于邻近微腔的顶部开口的壁的至少一部分具有相对于微腔的纵向轴线有效角度α的倾斜。 有效角度α可以大于45度且小于90度，并且至少位于微腔的顶部开口附近的位于有效角度α处的壁的部分可以具有至少5倍的长度 微腔的横向尺寸。
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公开(公告)号：US20150292995A1
公开(公告)日：2015-10-15
申请号：US14747837
申请日：2015-06-23
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Manjiri T. Kshirsagar , Kurt J. Halverson , Raj Rajagopal
IPC: G01N1/40
CPC classification number: G01N1/4077 , C12M47/04 , C12Q1/24 , G01N1/405 , G01N33/1866 , G01N2001/4088
Abstract: Kits and systems for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the kit including concentration agent; and a system for isolating microorganisms from a sample.
Abstract translation: 用于从样品中分离微生物的试剂盒和系统，样品包括样品基质和微生物，试剂盒包括浓缩剂; 以及用于从样品中分离微生物的系统。
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公开(公告)号：US20230273119A1
公开(公告)日：2023-08-31
申请号：US18111056
申请日：2023-02-17
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Bharat R. Acharya , Raj Rajagopal , Gregory W. Sitton , Benjamin G. Sonnek , Robert M. Biegler , Gilles J. Benoit , Timothy J. Lindquist , John A. Wheatley , Kristal L. Schutta , James A. Phipps
IPC: G01N21/31
CPC classification number: G01N21/314 , G01N2021/317 , G01N2201/0453
Abstract: An optical well is configured to receive a test sample for examining an optical characteristic of the sample at a first wavelength in a predetermined wavelength range. The optical well includes a wall having a bottom wall portion and a sidewall portion defining a chamber for receiving the test sample, and an optical film formed into a shape so that a portion of the sidewall portion includes a first portion of the optical film, and a portion of the bottom wall portion includes a second portion of the optical film. For a normally incident light, the microlayers in each of the first and second portions have an average optical reflectance of greater than about 80% in the predetermined wavelength range. The forming results in the plurality of microlayers of the integral formed optical film having a thinnest portion and a thickest portion having a thickness difference of at least 30%.
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Patent Agency Ranking
6.发明申请公开(公告)号：US20220115092A1
公开(公告)日：2022-04-14
申请号：US17431196
申请日：2020-01-27
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Wilfredo Dominguez-Nunez , Raj Rajagopal , Nicholas A. Asendorf , Saber Taghvaeeyan
Abstract: In some examples, a system for amplifying and quantifying a target organism present in a sample includes a detection device configured to amplify and detect a nucleic acid associated with the target organism. The detection device configured to receive a sample and to amplify nucleic acid in the sample over an amplification cycle. The detection device is configured to capture a data set including measurements of the nucleic acid collected during the amplification cycle. The system further includes a computing device configured to receive the data set and to apply a machine learning system to the data set. The machine learning system is trained to estimate a quantity of the target organism present in the sample based on the measurements in the data set.
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公开(公告)号：US20170248503A1
公开(公告)日：2017-08-31
申请号：US15594431
申请日：2017-05-12
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Manjiri T. Kshirsagar , Kurt J. Halverson , Raj Rajagopal
IPC: G01N1/40
Abstract: Kits and systems for isolating microorganisms from a sample, the sample including sample matrix and microorganisms, the kit including concentration agent; and a system for isolating microorganisms from a sample.
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公开(公告)号：US20200088615A1
公开(公告)日：2020-03-19
申请号：US16467658
申请日：2017-11-29
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Abstract: Systems and methods for detecting an analyte of interest. The method can include providing a container (102) adapted to receive a sample (152). The container can include a microstructured surface (130). The method can further include positioning a sample in the container; adding an H2S probe and an enzyme substrate to the container; centrifuging the container toward the microstructured surface to form a sediment and a supernatant of the sample; inverting the container, after centrifuging the container, to remove at least a portion of the supernatant from being in contact with the microstructured surface; and interrogating the concentrate in the microstructured surface for the analyte of interest.
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9.发明申请SYSTEMS AND METHODS FOR SAMPLE CONCENTRATION AND DETECTION USING A SEPARATION LIQUID 审中-公开使用分离液体进行样品浓缩和检测的系统和方法公开(公告)号：US20160310941A1
公开(公告)日：2016-10-27
申请号：US15105063
申请日：2014-12-16
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Raj Rajagopal , Kurt J. Halverson
CPC classification number: B01L3/50215 , B01L3/5021 , B01L2200/0605 , B01L2200/0631 , B01L2200/0642 , B01L2200/0673 , B01L2300/0636 , B01L2300/0681 , B01L2300/0832 , B01L2300/0893 , B01L2300/161 , B01L2400/0409 , C12Q1/24
Abstract: Systems and methods for concentrating a sample and detecting an analyte of interest using a separation liquid. The system can include a sample detection container that can include a microcavity. The microcavity can include a concentrate of a sample resulting from centrifugation of the sample. The container can further include a separation liquid located between the microcavity and a supernatant of the sample located outside of the microcavity. The separation liquid can have a density greater than that of the supernatant of the sample, and an interfacial tension with the supernatant of at least 0.05 N/m. The separation liquid can be non-toxic and inert. The method can include adding the separation liquid to the sample detection container, after centrifuging the sample detection container, to displace the supernatant located outside of the microcavity from the microcavity.
Abstract translation: 使用分离液浓缩样品和检测感兴趣分析物的系统和方法。 该系统可以包括可以包括微腔的样本检测容器。 微腔可以包括由样品离心引起的样品的浓缩物。 容器还可以包括位于微腔和位于微腔之外的样品的上清液之间的分离液体。 分离液的密度大于样品上清液的密度，上清液的界面张力至少为0.05N / m。 分离液可以是无毒的和惰性的。 该方法可以包括在离心样品检测容器之后将分离液添加到样品检测容器中，以将位于微腔外部的上清液置于微腔中。
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公开(公告)号：US09382570B2
公开(公告)日：2016-07-05
申请号：US14069416
申请日：2013-11-01
Applicant: 3M INNOVATIVE PROPERTIES COMPANY
Inventor： Raj Rajagopal , Kurt J. Halverson , Manjiri T. Kshirsagar , James E. Aysta
IPC: C12M1/34 , C12M3/00 , C12M1/00 , C12Q1/68 , G01N15/06 , G01N33/00 , G01N33/48 , C12Q1/04 , B01L3/00 , C12M1/24 , C12M1/30 , G01N33/569 , A61B10/00 , A61B10/02
CPC classification number: C12Q1/04 , A61B10/0045 , A61B10/02 , B01L3/5082 , B01L2200/026 , B01L2200/10 , C12M23/08 , C12M23/32 , C12M23/34 , C12M33/02 , G01N33/56916 , G01N2333/245
Abstract: The present invention provides methods to concentrate cells onto microparticles, to concentrate the microparticles, and to detect the cells. The present invention also includes unitary sample preparation and detection devices to be used in accordance with the methods.
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