- 专利标题： Drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases
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申请号： US16054416申请日： 2018-08-03
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公开(公告)号： US10435373B2公开(公告)日： 2019-10-08
- 发明人: Armin Giese , Uwe Bertsch , Hans Kretzschmar , Matthias Habeck , Thomas Hirschberger , Paul Tavan , Christian Griesinger , Andrei Leonov , Sergey Ryazanov , Petra Frick née Weber , Markus Geissen , Martin H. Groschup , Jens Wagner
- 申请人： LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN , MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
- 申请人地址： DE Munich DE Munich
- 专利权人： LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN,MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
- 当前专利权人： LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN,MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.
- 当前专利权人地址： DE Munich DE Munich
- 代理机构： Foley & Lardner LLP
- 优先权： EP08010458 20080609
- 主分类号： C07D231/12
- IPC分类号： C07D231/12 ; C07D207/333 ; C07D231/06 ; C07D233/64 ; C07D261/08 ; C07D271/06 ; C07D405/04 ; C07D413/04 ; A61K31/40 ; A61K31/415 ; A61K31/4155 ; A61K31/4164 ; A61K31/42 ; A61K31/4245 ; G01N33/68
摘要：
The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.
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