专利检索 ap:("LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN" OR "MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.") AND inv:"Markus Geissen" 第 1 页

1.

发明授权
Drug for inhibiting aggregation of proteins involved in diseases linked to protein aggregation and/or neurodegenerative diseases 有权

公开(公告)号：US10435373B2

公开(公告)日：2019-10-08

申请号：US16054416

申请日：2018-08-03

申请人： LUDWIG-MAXIMILIANS-UNIVERSITAT MUNCHEN , MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN E.V.

发明人： Armin Giese , Uwe Bertsch , Hans Kretzschmar , Matthias Habeck , Thomas Hirschberger , Paul Tavan , Christian Griesinger , Andrei Leonov , Sergey Ryazanov , Petra Frick née Weber , Markus Geissen , Martin H. Groschup , Jens Wagner

IPC分类号： C07D231/12 , C07D207/333 , C07D231/06 , C07D233/64 , C07D261/08 , C07D271/06 , C07D405/04 , C07D413/04 , A61K31/40 , A61K31/415 , A61K31/4155 , A61K31/4164 , A61K31/42 , A61K31/4245 , G01N33/68

摘要： The present invention relates to a compound represented by formula (E). The present invention also relates to a compound represented by the formula (E) for use in the treatment or prevention of diseases linked to protein aggregation and/or neurodegenerative diseases. Moreover, the present invention relates to pharmaceutical and diagnostic compositions comprising the compound of the invention as well as to a kit. Furthermore, the present invention relates to a method of imaging deposits of aggregated protein. A kit for preparing a detectably labelled compound of the present invention is also disclosed.