- 专利标题： Compositions and methods for dengue virus chimeric constructs in vaccines
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申请号： US15492981申请日： 2017-04-20
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公开(公告)号： US10449231B2公开(公告)日： 2019-10-22
- 发明人: Dan T. Stinchcomb , Claire Kinney , Richard M. Kinney , Jill A. Livengood
- 申请人： Takeda Vaccines, Inc. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： US MA Cambridge US GA Atlanta
- 专利权人： TAKEDA VACCINES, INC.,The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： TAKEDA VACCINES, INC.,The Government of the United States of America as Represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： US MA Cambridge US GA Atlanta
- 代理机构： Nath, Goldberg & Meyer
- 代理商 Joshua B. Goldberg; Scott H. Blackman
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N15/09 ; A61K38/16 ; A61K31/713 ; C07K14/005 ; A61K31/7048 ; C07K14/18 ; C07K19/00 ; C12N15/861 ; A61K39/00 ; A61P31/14
摘要：
Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.
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