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公开(公告)号：US10449231B2
公开(公告)日：2019-10-22
申请号：US15492981
申请日：2017-04-20
申请人： Takeda Vaccines, Inc. , THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES
IPC分类号： A61K39/12 , C12N15/09 , A61K38/16 , A61K31/713 , C07K14/005 , A61K31/7048 , C07K14/18 , C07K19/00 , C12N15/861 , A61K39/00 , A61P31/14
摘要： Embodiments herein report compositions, uses and manufacturing of dengue virus constructs and live attenuated dengue viruses. Some embodiments concern a composition that includes, but is not limited to, a tetravalent dengue virus composition. In certain embodiments, compositions can include constructs of one or more serotypes of dengue virus, such as dengue-1 (DEN-1) virus, dengue-2 (DEN-2) virus, dengue-3 (DEN-3) or dengue-4 (DEN-4) virus constructs. In other embodiments, constructs disclosed herein can be combined in a composition to generate a vaccine against more one or more dengue virus constructs that may or may not be subsequently passaged in mammalian cells.
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公开(公告)号：US20150150961A1
公开(公告)日：2015-06-04
申请号：US14407012
申请日：2013-12-19
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject against all dengue virus serotypes. In some embodiments, multiple vaccine compositions may be administered to a subject in different anatomical locations in order to induce a rapid response to all dengue virus serotypes. In certain embodiments, administration of two or more vaccine compositions to a subject against all dengue virus serotypes may include two or more routes of administration.
摘要翻译： 本发明的实施方案报道了针对所有登革热病毒血清型接种受试者的组合物和方法。 在一些实施方案中，可以将多种疫苗组合物施用于不同解剖位置的受试者，以便诱导对所有登革热病毒血清型的快速反应。 在某些实施方案中，将两种或更多种疫苗组合物施用于所有登革热病毒血清型的受试者可包括两种或更多种施用途径。
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公开(公告)号：US20180251737A1
公开(公告)日：2018-09-06
申请号：US15856770
申请日：2017-12-28
IPC分类号： C12N7/00
CPC分类号： C12N7/00 , C12N2770/24134 , C12N2770/24151
摘要： Embodiments herein report methods, compositions and uses for inducing and/or accelerating viral growth. In certain embodiments, methods, compositions and uses generally related to copolymer compositions for inducing viral growth, reducing lag time and/or increasing viral plaque size. In other embodiments, methods, compositions and uses of copolymer compositions can be for inducing flaviviral growth, reducing lag in growth and/or increasing plaque size.
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公开(公告)号：US10010600B2
公开(公告)日：2018-07-03
申请号：US14935281
申请日：2015-11-06
CPC分类号： A61K39/12 , A61K9/0019 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386 , Y02A50/407
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject against dengue viruses. In some embodiments, vaccine compositions may be administered by intradermal introduction. In certain embodiments, intradermal introduction in a subject of a vaccine against dengue virus may include one or more intradermal boosts after initial vaccination. Other embodiments include intradermal injection of a vaccine composition against dengue virus wherein the composition provides protection against two or more of DEN-1, DEN-2, DEN-3 and DEN-4.
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公开(公告)号：US09878031B2
公开(公告)日：2018-01-30
申请号：US14652066
申请日：2013-12-07
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject using trivalent dengue virus vaccine compositions. In some embodiments, more than one vaccine composition may be administered to a subject in different anatomical locations in order to induce a rapid response to at least three of four dengue virus serotypes. In certain embodiments, administration of a trivalent dengue virus vaccine composition can be combined with administration of a monovalent dengue virus vaccine composition.
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公开(公告)号：US20190134182A1
公开(公告)日：2019-05-09
申请号：US16159221
申请日：2018-10-12
摘要： Embodiments herein relate to compositions of and methods for live attenuated alphaviruses. In certain embodiments, a live, attenuated virus composition includes, but is not limited to, one or more live, attenuated alphaviruses and compositions to reduce inactivation and/or degradation of the live, attenuated alphavirus. In other embodiments, the live, attenuated virus composition may be a vaccine composition. In yet other compositions, a live, attenuated alphavirus composition may include HEPES buffer. In other embodiments, the HEPES buffer may further include a carbohydrate and gelatin and/or a salt.
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公开(公告)号：US10052374B2
公开(公告)日：2018-08-21
申请号：US15195820
申请日：2016-06-28
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Embodiments herein report compositions, methods and uses for dengue-4 (DENV-4) virus constructs. Some embodiments concern a composition that includes, but is not limited to, DENV-4 virus constructs alone or in combination with other constructs, can be used in a vaccine composition to induce an immune response in a subject. In certain embodiments, compositions can include constructs of more than one serotypes of dengue virus, such as dengue-1 virus, dengue-2 virus, or dengue-3 virus in combination with DENV-4 virus constructs disclosed herein. In other embodiments, DENV-4 constructs disclosed herein can be combined in a composition with other flavivirus constructs to generate a vaccine against more than one flavivirus. Other embodiments provide methods and uses for DENV-4 virus constructs in vaccine compositions that when administered to a subject induce an immune response in the subject against DENV-4 that is improved by modified constructs compared to other vaccine compositions.
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8.发明申请公开(公告)号：US20180228887A1
公开(公告)日：2018-08-16
申请号：US15844030
申请日：2017-12-15
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject using trivalent dengue virus vaccine compositions. In some embodiments, more than one vaccine composition may be administered to a subject in different anatomical locations in order to induce a rapid response to at least three of four dengue virus serotypes. In certain embodiments, administration of a trivalent dengue virus vaccine composition can be combined with administration of a monovalent dengue virus vaccine composition.
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公开(公告)号：US09713638B2
公开(公告)日：2017-07-25
申请号：US14407012
申请日：2013-06-10
CPC分类号： A61K39/12 , A61K45/06 , A61K2039/5254 , A61K2039/54 , A61K2039/545 , A61K2039/70 , C12N2770/24134 , Y02A50/386
摘要： Embodiments of the present invention report compositions and methods for vaccinating a subject against all dengue virus serotypes. In some embodiments, multiple vaccine compositions may be administered to a subject in different anatomical locations in order to induce a rapid response to all dengue virus serotypes. In certain embodiments, administration of two or more vaccine compositions to a subject against all dengue virus serotypes may include two or more routes of administration.
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10.发明申请公开(公告)号：US20170049874A1
公开(公告)日：2017-02-23
申请号：US15195820
申请日：2016-06-28
CPC分类号： A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/53 , A61K2039/575 , A61K2039/70 , C12N7/00 , C12N2770/24121 , C12N2770/24122 , C12N2770/24134 , C12N2770/24171 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： Embodiments herein report compositions, methods and uses for dengue-4 (DENV-4) virus constructs. Some embodiments concern a composition that includes, but is not limited to, DENV-4 virus constructs alone or in combination with other constructs, can be used in a vaccine composition to induce an immune response in a subject. In certain embodiments, compositions can include constructs of more than one serotypes of dengue virus, such as dengue-1 virus, dengue-2 virus, or dengue-3 virus in combination with DENV-4 virus constructs disclosed herein. In other embodiments, DENV-4 constructs disclosed herein can be combined in a composition with other flavivirus constructs to generate a vaccine against more than one flavivirus. Other embodiments provide methods and uses for DENV-4 virus constructs in vaccine compositions that when administered to a subject induce an immune response in the subject against DENV-4 that is improved by modified constructs compared to other vaccine compositions.
摘要翻译： 本文的实施方案报告了登革4（DENV-4）病毒构建体的组合物，方法和用途。 一些实施方案涉及包括但不限于单独的DENV-4病毒构建体或与其它构建体组合的组合物，可用于疫苗组合物中以在受试者中诱导免疫应答。 在某些实施方案中，组合物可以包括与本文公开的DENV-4病毒构建体结合的登革热病毒如登革热病毒，登革热-2病毒或登革热-3病毒的多于一种血清型的构建体。 在其它实施方案中，本文公开的DENV-4构建体可以与其他黄病毒构建体组合在一起，以产生针对多于一种黄病毒的疫苗。 其他实施方案提供疫苗组合物中DENV-4病毒构建体的方法和用途，当施用于受试者时，诱导针对DENV-4的受试者的免疫应答，其与其它疫苗组合物相比被修饰的构建体改善。
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