Embodiments are provided to serve user equipments (UEs) that experience, for example persistently, inter-transmission point group (TPG) interference in a wireless or cellular network. The embodiments include steps to serve edge UEs (EUs) such as persistent EUs (PEUs) using a set of transmission points (TPs) in one or more TPGs. The selected set of TPs used for serving the EUs or PEUs are dynamically determined based on a UE-centric metric. The metric involves the PEUs and surrounding UEs. The UE-centric metric is used to partition the network to multiple TPG sets. For each one of multiple assigned resource units (RUs), a TPG set that maximizes or improves a network-wide utility is used for scheduling transmissions. Further, for each RU, the UEs are associated with an optimized or improved TPG in the used TPG set.