Transistor devices may be formed having a buffer between an active channel and a substrate, wherein the active channel and a portion of the buffer form a gated region. The active channel may comprise a low band-gap material on a sub-structure, e.g. the buffer, between the active channel and the substrate. The sub-structure may comprise a high band-gap material having a desired conduction band offset, such that leakage may be arrested without significant impact on electron mobility within the active channel. In an embodiment, the active channel and the sub-structure may be formed in a narrow trench, such that defects due to lattice mismatch between the active channel and the sub-structure are terminated in the sub-structure.