Methods and apparatus for multiple user uplink are provided. In one aspect, a method for wireless communication includes receiving, via a first device, a first wireless message granting permission for the first device to transmit a message during a transmission opportunity, the first wireless message being transmitted to the first device at least partially concurrently with a transmission of at least a portion of a second wireless message addressed to a second device, the first wireless message being received over a first spatial stream and the second wireless message being transmitted over a second spatial stream; and transmitting, via the first device, a third message to a third device during the transmission opportunity at least partially concurrently with a transmission of a fourth message by the second device to the third device.