- 专利标题: Inhibitors of LDLR-PCSK9 protein-protein interaction and methods of their use
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申请号: US16334285申请日: 2017-09-19
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公开(公告)号: US10577357B2公开(公告)日: 2020-03-03
- 发明人: Kevin Burgess
- 申请人: The Texas A&M University System
- 申请人地址: US TX College Station
- 专利权人: The Texas A&M University System
- 当前专利权人: The Texas A&M University System
- 当前专利权人地址: US TX College Station
- 代理机构: Wolf, Greenfield & Sacks, P.C.
- 国际申请: PCT/US2017/052292 WO 20170919
- 国际公布: WO2018/053517 WO 20180322
- 主分类号: C07D241/04
- IPC分类号: C07D241/04 ; C07D241/12 ; C07D403/06 ; C07D405/14 ; A61P3/06 ; C07D233/02 ; C07D403/14
摘要:
Compounds that disrupt the interaction between PCSK9 and LDLR, compositions that include the compounds, and methods for making and using the compounds and compositions.