Invention Grant
- Patent Title: Glypican-3-binding fibronectin based scaffold molecules
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Application No.: US15760449Application Date: 2016-09-22
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Publication No.: US10584160B2Publication Date: 2020-03-10
- Inventor: Dasa Lipovsek , Joseph Toth , Ginger C. Rakestraw , Irvith M. Carvajal , Stanley Richard Krystek, Jr. , Steven R. O'Neil , Guodong Chen , Richard Y. Huang , Bryan C. Barnhart , John Thomas Loffredo , Christina Terragni
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Agency: Nelson Mullins Riley & Scarborough LLP
- Agent Jane E. Remillard, Esq.; Cynthia L. Kanik
- International Application: PCT/US2016/053185 WO 20160922
- International Announcement: WO2017/053619 WO 20170330
- Main IPC: C07K14/78
- IPC: C07K14/78 ; A61K47/64 ; G01N33/68 ; A61K38/00
Abstract:
Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.
Public/Granted literature
- US20190077844A1 GLYPICAN-3-BINDING FIBRONECTIN BASED SCAFFOLD MOLECULES Public/Granted day:2019-03-14
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