公开(公告)号：US10774130B2

公开(公告)日：2020-09-15

申请号：US15866919

申请日：2018-01-10

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/05 ,  C07K14/78 ,  C07K16/46 ,  C07K16/28 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K38/39 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.

公开(公告)号：US10584160B2

公开(公告)日：2020-03-10

申请号：US15760449

申请日：2016-09-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek ,  Joseph Toth ,  Ginger C. Rakestraw ,  Irvith M. Carvajal ,  Stanley Richard Krystek, Jr. ,  Steven R. O'Neil ,  Guodong Chen ,  Richard Y. Huang ,  Bryan C. Barnhart ,  John Thomas Loffredo ,  Christina Terragni

IPC: C07K14/78 ,  A61K47/64 ,  G01N33/68 ,  A61K38/00

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

公开(公告)号：US11524992B2

公开(公告)日：2022-12-13

申请号：US16751788

申请日：2020-01-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek ,  Joseph Toth ,  Ginger C. Rakestraw ,  Irvith M. Carvajal ,  Stanley Richard Krystek, Jr. ,  Steven R. O'Neil ,  Guodong Chen ,  Richard Y. Huang ,  Bryan C. Barnhart ,  John Thomas Loffredo ,  Christina Terragni

IPC: C07K14/78 ,  A61K47/64 ,  G01N33/68 ,  A61K38/00 ,  A61K47/60

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

公开(公告)号：US09902762B2

公开(公告)日：2018-02-27

申请号：US14229415

申请日：2014-03-28

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ray Camphausen ,  Eric Furfine ,  Irvith M. Carvajal ,  H. Nicholas Marsh ,  Marco Gottardis ,  Joan Carboni ,  Ricardo Attar

IPC: C07K14/705 ,  C07K14/78 ,  C07K14/435 ,  C07K16/46 ,  C07K16/28 ,  A61K38/39 ,  A61K38/16 ,  A61K38/17 ,  A61K38/18 ,  A61K47/60 ,  A61K39/395 ,  C07K14/71 ,  C07K14/715 ,  A61K39/00

CPC classification number: C07K14/78 ,  A61K38/39 ,  A61K39/3955 ,  A61K47/60 ,  A61K2039/505 ,  C07K14/71 ,  C07K14/715 ,  C07K16/2863 ,  C07K2317/31 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2318/20 ,  C07K2319/00 ,  C07K2319/74

Abstract: The present invention relates to multivalent polypeptides comprising at least two fibronectin scaffold domains connected via a polypeptide linker. The invention also relates to multivalent polypeptides for use in diagnostic, research and therapeutic applications. The invention further relates to cells comprising such proteins, polynucleotide encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the innovative proteins.