公开(公告)号：US10584160B2

公开(公告)日：2020-03-10

申请号：US15760449

申请日：2016-09-22

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek ,  Joseph Toth ,  Ginger C. Rakestraw ,  Irvith M. Carvajal ,  Stanley Richard Krystek, Jr. ,  Steven R. O'Neil ,  Guodong Chen ,  Richard Y. Huang ,  Bryan C. Barnhart ,  John Thomas Loffredo ,  Christina Terragni

IPC: C07K14/78 ,  A61K47/64 ,  G01N33/68 ,  A61K38/00

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.

公开(公告)号：US11524992B2

公开(公告)日：2022-12-13

申请号：US16751788

申请日：2020-01-24

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Dasa Lipovsek ,  Joseph Toth ,  Ginger C. Rakestraw ,  Irvith M. Carvajal ,  Stanley Richard Krystek, Jr. ,  Steven R. O'Neil ,  Guodong Chen ,  Richard Y. Huang ,  Bryan C. Barnhart ,  John Thomas Loffredo ,  Christina Terragni

IPC: C07K14/78 ,  A61K47/64 ,  G01N33/68 ,  A61K38/00 ,  A61K47/60

Abstract: Provided herein are polypeptides which include tenth fibronectin type III domains (10Fn3) that bind to glypican-3. Also provided are fusion molecules comprising a 10Fn3 domain that bind to glypican-3 for use in diagnostic and therapeutic applications. Glypican-3 10Fn3 drug conjugates are also provided.