- 专利标题： Macrocyclic MCL-1 inhibitors and methods of use
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申请号： US15998789申请日： 2018-08-15
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公开(公告)号： US10676485B2公开(公告)日： 2020-06-09
- 发明人: Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Zhi-Fu Tao , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Thomas D. Penning
- 申请人： AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
- 申请人地址： US IL North Chicago
- 专利权人： AbbVie Inc.
- 当前专利权人： AbbVie Inc.
- 当前专利权人地址： US IL North Chicago
- 代理商 Laura E. Johannes
- 主分类号： A61K31/395
- IPC分类号： A61K31/395 ; A61P35/02 ; C07D495/16 ; C07D495/18 ; A61K45/06 ; C07D495/22 ; C07D491/18 ; A61K31/519 ; C07D491/22 ; A61P35/00
摘要：
The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
公开/授权文献
- US20190144465A1 Macrocyclic MCL-1 inhibitors and methods of use 公开/授权日：2019-05-16
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