Invention Grant
- Patent Title: Macrocyclic MCL-1 inhibitors and methods of use
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Application No.: US15998789Application Date: 2018-08-15
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Publication No.: US10676485B2Publication Date: 2020-06-09
- Inventor: Andrew S. Judd , Aaron R. Kunzer , Chunqiu Lai , Andrew J. Souers , Zhi-Fu Tao , Anthony Mastracchio , Xilu Wang , Cheng Ji , Michael D. Wendt , Xiaohong Song , George A. Doherty , Thomas D. Penning
- Applicant: AbbVie Inc. , AbbVie Deutschland GmbH & Co. KG
- Applicant Address: US IL North Chicago
- Assignee: AbbVie Inc.
- Current Assignee: AbbVie Inc.
- Current Assignee Address: US IL North Chicago
- Agent Laura E. Johannes
- Main IPC: A61K31/395
- IPC: A61K31/395 ; A61P35/02 ; C07D495/16 ; C07D495/18 ; A61K45/06 ; C07D495/22 ; C07D491/18 ; A61K31/519 ; C07D491/22 ; A61P35/00
Abstract:
The present disclosure provides for compounds of formula (I) wherein A2, A3, A4, A6, A7, A8, A15, RA, R5, R9, R10A, R10B, R11, R12, R13, R14, R16, W, X, and Y have any of the values defined in the specification, and pharmaceutically acceptable salts thereof, that are useful as agents in the treatment of diseases and conditions, including cancer. Also provided are pharmaceutical compositions comprising compounds of formula (I).
Public/Granted literature
- US20190144465A1 Macrocyclic MCL-1 inhibitors and methods of use Public/Granted day:2019-05-16
Information query
