Invention Grant
- Patent Title: Substituted urea depsipeptide analogs as activators of the ClpP endopeptidase
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Application No.: US15863673Application Date: 2018-01-05
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Publication No.: US10676510B2Publication Date: 2020-06-09
- Inventor: Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
- Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- Applicant Address: US TN Memphis
- Assignee: St. Jude Children's Research Hospital
- Current Assignee: St. Jude Children's Research Hospital
- Current Assignee Address: US TN Memphis
- Agency: Ballard Spahr LLP
- Main IPC: C07K11/02
- IPC: C07K11/02 ; A61K38/15 ; A61K45/06 ; C12N9/50 ; C07K7/06 ; A61K38/00
Abstract:
In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Public/Granted literature
- US20180127469A1 SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE Public/Granted day:2018-05-10
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