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1.发明申请SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE 有权作为CLPP内切酶的激活剂的替代尿素抑制剂模拟物公开(公告)号：US20160200770A1
公开(公告)日：2016-07-14
申请号：US14914449
申请日：2014-08-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
CPC classification number: C07K11/02 , A61K38/00 , A61K38/15 , A61K45/06 , C07K7/06 , C12N9/50 , C12Y304/21 , Y02A50/471 , Y02A50/475 , Y02A50/481
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Abstract translation: 一方面，本发明涉及用作活化剂ClpP内肽酶的取代的脲缩酚酸酯类似物，其衍生物和相关化合物， 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗传染病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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Patent Agency Ranking
公开(公告)号：US10676510B2
公开(公告)日：2020-06-09
申请号：US15863673
申请日：2018-01-05
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10266544B2
公开(公告)日：2019-04-23
申请号：US15024549
申请日：2014-09-29
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Richard E. Lee , Samanthi L. Waidyarachchi , David F. Bruhn , Jiuyu Liu , Zhong Zheng , Jason W. Rosch
IPC: C07D493/04 , A61K9/00 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/4178 , A61K31/427 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61K45/06
Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.
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4.发明申请ARYL SUBSTITUTED AMINOMETHYL SPECTINOMYCIN ANALOGS AS ANTIBACTERIAL AGENTS 审中-公开ARYL取代的氨基甲酰胺类化合物作为抗菌剂公开(公告)号：US20160347762A1
公开(公告)日：2016-12-01
申请号：US15024549
申请日：2014-09-29
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Richard E. Lee , Samanthi L. Waidyarachchi , David F. Bruhn , Jiuyu Liu , Zhong Zheng , Jason W. Rosch
IPC: C07D493/04 , A61K45/06 , A61K9/00 , A61K31/4433 , A61K31/381 , A61K31/497 , A61K31/4178 , A61K31/428 , A61K31/4045 , A61K31/4025 , A61K31/5377 , A61K31/357 , A61K31/427
CPC classification number: C07D493/04 , A61K9/0019 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/4178 , A61K31/427 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61K45/06
Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.
Abstract translation: 本发明涉及可用作抗菌剂的芳基取代氨基甲基壮观霉素类似物，其衍生物和相关化合物; 制备化合物的方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗抗菌感染的方法。
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公开(公告)号：US09879050B2
公开(公告)日：2018-01-30
申请号：US14914449
申请日：2014-08-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
CPC classification number: C07K11/02 , A61K38/00 , A61K38/15 , A61K45/06 , C07K7/06 , C12N9/50 , C12Y304/21 , Y02A50/471 , Y02A50/475 , Y02A50/481
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20180127469A1
公开(公告)日：2018-05-10
申请号：US15863673
申请日：2018-01-05
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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