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公开(公告)号：US10457707B2
公开(公告)日：2019-10-29
申请号：US16160724
申请日：2018-10-15
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
IPC: A61K38/00 , C07K9/00 , C07K11/02 , A61K38/12 , A61K31/407 , A61K38/14 , A61K45/06 , C07D498/14 , C07D498/22 , C07K7/06 , A61K9/00 , A61K47/02 , A61K9/20 , A61K38/15
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20180127469A1
公开(公告)日：2018-05-10
申请号：US15863673
申请日：2018-01-05
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10676510B2
公开(公告)日：2020-06-09
申请号：US15863673
申请日：2018-01-05
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20190048040A1
公开(公告)日：2019-02-14
申请号：US16160724
申请日：2018-10-15
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
IPC: C07K11/02 , C07D498/14 , A61K38/15 , A61K9/20 , A61K47/02 , A61K9/00 , C07D498/22 , A61K45/06 , C07K7/06 , A61K38/12 , A61K38/14 , A61K31/407
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10822377B2
公开(公告)日：2020-11-03
申请号：US16588738
申请日：2019-09-30
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
IPC: A61K38/00 , C07K11/02 , A61K38/12 , A61K31/407 , A61K38/14 , A61K45/06 , C07D498/14 , C07D498/22 , C07K7/06 , A61K9/00 , A61K47/02 , A61K9/20 , A61K38/15
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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Patent Agency Ranking
公开(公告)号：US10570179B2
公开(公告)日：2020-02-25
申请号：US16329168
申请日：2017-09-01
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20180079784A1
公开(公告)日：2018-03-22
申请号：US15554707
申请日：2016-03-04
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
CPC classification number: C07K11/02 , A61K9/0019 , A61K9/2018 , A61K31/407 , A61K38/12 , A61K38/14 , A61K38/15 , A61K45/06 , A61K47/02 , C07D498/14 , C07D498/22 , C07K7/06 , Y02A50/469 , Y02A50/471 , Y02A50/475 , Y02A50/481 , A61K2300/00
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of search in the particular art and is not intended to be limiting of the present invention.
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8.发明申请SUBSTITUTED UREA DEPSIPEPTIDE ANALOGS AS ACTIVATORS OF THE CLPP ENDOPEPTIDASE 有权作为CLPP内切酶的激活剂的替代尿素抑制剂模拟物公开(公告)号：US20160200770A1
公开(公告)日：2016-07-14
申请号：US14914449
申请日：2014-08-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
CPC classification number: C07K11/02 , A61K38/00 , A61K38/15 , A61K45/06 , C07K7/06 , C12N9/50 , C12Y304/21 , Y02A50/471 , Y02A50/475 , Y02A50/481
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
Abstract translation: 一方面，本发明涉及用作活化剂ClpP内肽酶的取代的脲缩酚酸酯类似物，其衍生物和相关化合物， 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗传染病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。
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公开(公告)号：US20190185517A1
公开(公告)日：2019-06-20
申请号：US16329168
申请日：2017-09-01
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. LEE , Ying Zhao
CPC classification number: C07K11/02 , A61K38/00 , A61K38/15 , A61K45/06 , A61P31/00 , A61P31/04 , C07K7/06
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10100090B2
公开(公告)日：2018-10-16
申请号：US15554707
申请日：2016-03-04
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with the ClpP endopeptidase; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of search in the particular art and is not intended to be limiting of the present invention.
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