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公开(公告)号：US11891378B2
公开(公告)日：2024-02-06
申请号：US16958022
申请日：2018-12-26
Inventor： Richard E. Lee , Rajendra P. Tangallapally , Charles O. Rock , Suzanne Jackowski , Anne V. Edwards , Mi Kyung Yun , Chitra Subramanian , Robert Zamboni , T. Jagadeeswar Reddy
IPC: C07D403/04 , A61K31/197
CPC classification number: C07D403/04 , A61K31/197
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20190300499A1
公开(公告)日：2019-10-03
申请号：US16307473
申请日：2017-06-23
Applicant: St. Jude Children's Research Hospital
Inventor： Lalit Kumar Sharma , Richard E. Lee , Charles O. Rock , Suzanne Jackowski , Mi Kyung Yun , Chitra Subramanian , Jiuyu Liu
IPC: C07D401/04 , C07D413/14 , C07D241/04 , C07D401/14 , C07D409/14 , C07D403/12 , C07D403/04
Abstract: The present disclosure relates to chemical compounds that modulate pantothenate kinase (PanK) activity for the treatment of metabolic disorders (such as diabetes mellitus type II), neurologic disorders (such as pantothenate kinase-associated neurodegeneration), pharmaceutical compositions containing such compounds, and their use in treatment. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10100090B2
公开(公告)日：2018-10-16
申请号：US15554707
申请日：2016-03-04
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators with the ClpP endopeptidase; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of search in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10011589B2
公开(公告)日：2018-07-03
申请号：US15125451
申请日：2015-03-12
Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM , ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Richard E. Lee , Philip T. Cherian , Julian G. Hurdle , Xiaoqian Wu
IPC: C07D403/14 , C07D403/12 , C07D403/06
CPC classification number: C07D403/14 , C07D403/06 , C07D403/12
Abstract: Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use against C. difficile infections and comprise a hybrid molecule of an anti-C. difficile compound such as a nitroimidazole and a tetramic acid derivative.
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5.发明申请ARYL SUBSTITUTED AMINOMETHYL SPECTINOMYCIN ANALOGS AS ANTIBACTERIAL AGENTS 审中-公开ARYL取代的氨基甲酰胺类化合物作为抗菌剂公开(公告)号：US20160347762A1
公开(公告)日：2016-12-01
申请号：US15024549
申请日：2014-09-29
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Richard E. Lee , Samanthi L. Waidyarachchi , David F. Bruhn , Jiuyu Liu , Zhong Zheng , Jason W. Rosch
IPC: C07D493/04 , A61K45/06 , A61K9/00 , A61K31/4433 , A61K31/381 , A61K31/497 , A61K31/4178 , A61K31/428 , A61K31/4045 , A61K31/4025 , A61K31/5377 , A61K31/357 , A61K31/427
CPC classification number: C07D493/04 , A61K9/0019 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/4178 , A61K31/427 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61K45/06
Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.
Abstract translation: 本发明涉及可用作抗菌剂的芳基取代氨基甲基壮观霉素类似物，其衍生物和相关化合物; 制备化合物的方法; 包含该化合物的药物组合物; 以及使用该化合物和组合物治疗抗菌感染的方法。
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Patent Agency Ranking
公开(公告)号：US20250163075A1
公开(公告)日：2025-05-22
申请号：US18955510
申请日：2024-11-21
Applicant: St. Jude Children's Research Hospital , Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.
Inventor： Richard E. Lee , Suresh Dharuman , Daniel C. Scott , Jason M. Ochoada , Rajendra P. Tangallapally , Brenda A. Schulman
IPC: C07D495/14 , A61K31/496 , A61K31/506 , A61K31/551 , C07D417/14 , C07D471/04 , C07D519/00
Abstract: The present disclosure relates to compounds that bind to the kelch domain-containing protein 2 (KLHDC2) E3 ligase active site and heterobifunctional targeted protein degraders comprising the compounds. Methods of using these degraders in the treatment of cancer is also described. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US20200031872A1
公开(公告)日：2020-01-30
申请号：US16588738
申请日：2019-09-30
Applicant: St. Jude Children's Research Hospital
Inventor： Richard E. Lee , Ying Zhao , Liu Jiuyu
IPC: C07K11/02 , A61K38/12 , A61K31/407 , A61K38/14 , A61K45/06 , C07D498/14 , C07D498/22 , C07K7/06 , A61K9/00 , A61K47/02 , A61K9/20 , A61K38/15
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US09879050B2
公开(公告)日：2018-01-30
申请号：US14914449
申请日：2014-08-30
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
CPC classification number: C07K11/02 , A61K38/00 , A61K38/15 , A61K45/06 , C07K7/06 , C12N9/50 , C12Y304/21 , Y02A50/471 , Y02A50/475 , Y02A50/481
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the ClpP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10676510B2
公开(公告)日：2020-06-09
申请号：US15863673
申请日：2018-01-05
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
Inventor： Richard E. Lee , Ying Zhao , Elizabeth Griffith , Zhong Zheng , Aman P. Singh
Abstract: In one aspect, the invention relates to substituted urea depsipeptide analogs, derivatives thereof, and related compounds, which are useful as activators the C1pP endopeptidease; synthesis methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating infectious disease using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
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公开(公告)号：US10266544B2
公开(公告)日：2019-04-23
申请号：US15024549
申请日：2014-09-29
Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
Inventor： Richard E. Lee , Samanthi L. Waidyarachchi , David F. Bruhn , Jiuyu Liu , Zhong Zheng , Jason W. Rosch
IPC: C07D493/04 , A61K9/00 , A61K31/357 , A61K31/381 , A61K31/4025 , A61K31/4045 , A61K31/4178 , A61K31/427 , A61K31/428 , A61K31/4433 , A61K31/497 , A61K31/5377 , A61K45/06
Abstract: The invention relates to aryl substituted aminomethyl spectinomycin analogs, derivatives thereof, and related compounds, which are useful as anti-bacterial agents; methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating anti-bacterial infections using the compounds and compositions.
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