Invention Grant
- Patent Title: Microfluidic device and method for detecting rare cells
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Application No.: US16100726Application Date: 2018-08-10
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Publication No.: US10677708B2Publication Date: 2020-06-09
- Inventor: Sunitha Nagrath , Hyeun Joong Yoon , Eric Lin , Max S. Wicha , Lianette Rivera Baez , Diane M. Simeone
- Applicant: The Regents of the University of Michigan
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Howard & Howard Attorneys PLLC
- Main IPC: G01N15/10
- IPC: G01N15/10 ; B01L3/00 ; G01N33/50 ; G01N33/574 ; G01N15/02 ; C12Q1/04 ; G01N15/00

Abstract:
A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.
Public/Granted literature
- US20190017919A1 Microfluidic Device And Method For Detecting Rare Cells Public/Granted day:2019-01-17
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