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    SYSTEM FOR DETECTING RARE CELLS
    4.
    发明申请
    SYSTEM FOR DETECTING RARE CELLS 有权
    检测稀有细胞的系统

    公开(公告)号：US20140315213A1

    公开(公告)日：2014-10-23

    申请号：US14347073

    申请日：2012-09-28

    申请人： The Regents of the University of Michigan

    发明人： Sunitha Nagrath ,  Hyeun Joong Yoon

    IPC分类号： G01N33/574

    CPC分类号： G01N33/574 ,  B01L2300/0896 ,  B82Y15/00 ,  G01N33/54353 ,  G01N33/54386 ,  G01N33/553 ,  G01N33/57492

    摘要： This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.

    摘要翻译： 本公开提供了一种用于检测稀有细胞的系统。 该系统包括衬底，连接到衬底并从衬底向外延伸的延伸部分和设置在延伸部上的功能化石墨烯氧化物。 本公开还提供了使用本公开的系统来检测稀有电池的方法。 该方法包括以下步骤：提供系统并将体液样本引入系统，使得样品与官能化石墨烯氧化物相互作用。

    System for detecting rare cells
    6.
    发明授权
    System for detecting rare cells 有权

    公开(公告)号：US09568475B2

    公开(公告)日：2017-02-14

    申请号：US14347073

    申请日：2012-09-28

    申请人： The Regents of the University of Michigan

    发明人： Sunitha Nagrath ,  Hyeun Joong Yoon

    IPC分类号： G01N33/543 ,  G01N33/574 ,  G01N33/553 ,  B82Y15/00

    摘要： This disclosure provides a system for detecting rare cells. The system includes a substrate, an extension coupled to the substrate and extending outwardly from the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of providing the system and introducing a sample of bodily fluid to the system such that the sample interacts with the functionalized graphene oxide.

    Microfluidic device and method for detecting rare cells
    8.
    发明授权
    Microfluidic device and method for detecting rare cells 有权

    公开(公告)号：US10677708B2

    公开(公告)日：2020-06-09

    申请号：US16100726

    申请日：2018-08-10

    申请人： The Regents of the University of Michigan

    发明人： Sunitha Nagrath ,  Hyeun Joong Yoon ,  Eric Lin ,  Max S. Wicha ,  Lianette Rivera Baez ,  Diane M. Simeone

    IPC分类号： G01N15/10 ,  B01L3/00 ,  G01N33/50 ,  G01N33/574 ,  G01N15/02 ,  C12Q1/04 ,  G01N15/00

    摘要： A microfluidic device for detecting rare cells in a fluid sample comprises the rare cell and other cells. The microfluidic device comprises an inlet for receiving the fluid sample, a labyrinth channel structure in fluid communication with the inlet, and an outlet in fluid communication with the labyrinth channel structure for collecting the rare cells separated from the other cells in the fluid sample. The labyrinth channel structure comprises at least one channel through which the fluid sample flows. The at least one channel has a plurality of segments and a plurality of corners with each corner defined between adjacent segments. The presence of the plurality of corners induces separation of the rare cells from the other cells in the fluid sample as the rare cells move to a first equilibrium position within the at least one channel when a ratio of inertial lift forces (FZ) and Dean flow (FD) of the fluid sample is from 2 to 10.

    System for detecting rare cells
    9.
    发明授权
    System for detecting rare cells 有权

    公开(公告)号：US10317406B2

    公开(公告)日：2019-06-11

    申请号：US15091830

    申请日：2016-04-06

    申请人： The Regents of the University of Michigan

    发明人： Hyeun Joong Yoon ,  Apoorv Shanker ,  Jinsang Kim ,  Sunitha Nagrath ,  Vasudha Murlidhar

    IPC分类号： G01N33/543 ,  G01N33/574 ,  G01N33/545 ,  C08L33/26

    摘要： A system for detecting rare cells in a fluid is disclosed. The system includes a substrate and a mixture disposed on the substrate and including a carrier and a thermo-responsive polymer for capture and release of the rare cells. Also disclosed is a method for detecting rare cells in a fluid using a system including a substrate and a mixture that is disposed on the substrate. The mixture includes a carrier and a thermo-responsive polymer. The method includes providing the system and introducing a sample of fluid containing the rare cells into the system such that the sample interacts with the carrier for capturing the rare cells.

    System for detecting rare cells
    10.
    发明授权
    System for detecting rare cells 有权

    公开(公告)号：US10130946B2

    公开(公告)日：2018-11-20

    申请号：US14545181

    申请日：2015-04-06

    申请人： The Regents of the University of Michigan

    发明人： Sunitha Nagrath ,  Vasudha Murlidhar

    IPC分类号： B01L3/00 ,  G01N33/543

    摘要： This disclosure provides a system for detecting rare cells. The system includes a substrate, extensions extending outwardly from the substrate and arranged about a center axis of the substrate to define a channel enabling the fluid to move radially from the center axis to an outer edge of the substrate, and a functionalized graphene oxide disposed on the extension. This disclosure also provides a method for detecting rare cells using the system of this disclosure. The method includes the steps of introducing a sample of fluid containing the rare cells into the inlet of the system such that the sample of fluid flows radially from the inlet toward the outer edge of the substrate and capturing the rare cells as the rare cells interact with the functionalized graphene oxide disposed on the extensions.